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| H | ZESCO United | - | Horoya AC | 4:1 | ||
| R | Horoya AC | - | ZESCO United | 2:0 | ||
| H: 12.03.2016 14:00 | R: 20.03.2016 18:00 | Sieger: ZESCO United | ||||
| H | Al Ahly Tripolis | - | Al Hilal Omdurman | 1:0 | ||
| R | Al Hilal Omdurman | - | Al Ahly Tripolis | 2:1 | ||
| H: 12.03.2016 14:00 | R: 20.03.2016 18:00 | Sieger: Al Ahly Tripolis | ||||
| H | APR FC | - | Young Africans | 1:2 | ||
| R | Young Africans | - | APR FC | 1:1 | ||
| H: 12.03.2016 14:30 | R: 19.03.2016 14:00 | Sieger: Young Africans | ||||
| H | CRD Libolo | - | Al Ahly SC | 0:0 | ||
| R | Al Ahly SC | - | CRD Libolo | 2:0 | ||
| H: 12.03.2016 16:00 | R: 19.03.2016 18:00 | Sieger: Al Ahly SC | ||||
| H | Club Africain | - | MO Béjaïa | 1:0 | ||
| R | MO Béjaïa | - | Club Africain | 2:0 | ||
| H: 12.03.2016 17:00 | R: 20.03.2016 18:00 | Sieger: MO Béjaïa | ||||
| H | Stade Malien | - | Coton Sport Garoua | 2:0 | ||
| R | Coton Sport Garoua | - | Stade Malien | 1:0 | ||
| H: 12.03.2016 18:30 | R: 20.03.2016 15:00 | Sieger: Stade Malien | ||||
| H | Kaizer Chiefs | - | ASEC Mimosas | 0:1 | ||
| R | ASEC Mimosas | - | Kaizer Chiefs | 0:0 | ||
| H: 12.03.2016 18:30 | R: 20.03.2016 16:30 | Sieger: ASEC Mimosas | ||||
| H | Mamelodi Sundowns | - | AC Léopards | 2:0 | ||
| R | AC Léopards | - | Mamelodi Sundowns | 1:1 | ||
| H: 12.03.2016 19:15 | R: 19.03.2016 15:30 | Sieger: Mamelodi Sundowns | ||||
| H | Wydad AC | - | CNaPS Sports | 5:1 | ||
| R | CNaPS Sports | - | Wydad AC | 2:1 | ||
| H: 12.03.2016 20:45 | R: 19.03.2016 12:30 | Sieger: Wydad AC | ||||
| H | St. George SC | - | TP Mazembe | 2:2 | ||
| R | TP Mazembe | - | St. George SC | 1:0 | ||
| H: 13.03.2016 14:00 | R: 20.03.2016 14:30 | Sieger: TP Mazembe | ||||
| H | Union Sportive Douala | - | Zamalek | 0:1 | ||
| R | Zamalek | - | Union Sportive Douala | 2:0 | ||
| H: 13.03.2016 14:30 | R: 19.03.2016 19:00 | Sieger: Zamalek | ||||
| H | AS Vita Club | - | Clube Ferroviário Maputo | 1:0 | ||
| R | Clube Ferroviário Maputo | - | AS Vita Club | 1:1 | ||
| H: 13.03.2016 15:30 | R: 20.03.2016 14:00 | Sieger: AS Vita Club | ||||
| H | AS Etoile du Congo | - | ES Sétif | 1:1 | ||
| R | ES Sétif | - | AS Etoile du Congo | 4:2 | ||
| H: 13.03.2016 15:30 | R: 20.03.2016 18:00 | Sieger: ES Sétif | ||||
| H | Warri Wolves | - | Al Merrikh SC | 0:1 | ||
| R | Al Merrikh SC | - | Warri Wolves | 1:0 | ||
| H: 13.03.2016 16:00 | R: 19.03.2016 18:00 | Sieger: Al Merrikh SC | ||||
| H | Enyimba Aba | - | Vital'O | 5:1 | ||
| R | Vital'O | - | Enyimba Aba | 2:1 | ||
| H: 13.03.2016 16:00 | R: 19.03.2016 14:00 | Sieger: Enyimba Aba | ||||
| H | Olympique de Khouribga | - | Étoile du Sahel | 1:1 | ||
| R | Étoile du Sahel | - | Olympique de Khouribga | 2:0 | ||
| H: 13.03.2016 17:00 | R: 19.03.2016 16:30 | Sieger: Étoile du Sahel | ||||
