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| H | Deportes Tolima | - | Sportivo Luqueño | 1:1 (1:0) | ||
| R | Sportivo Luqueño | - | Deportes Tolima | 1:0 (0:0) | ||
| H: 23.09.2015 02:00 | R: 30.09.2015 00:00 | Sieger: Sportivo Luqueño | ||||
| H | River Plate | - | LDU Quito | 2:0 (1:0) | ||
| R | LDU Quito | - | River Plate | 1:0 (0:0) | ||
| H: 24.09.2015 00:00 | R: 01.10.2015 00:45 | Sieger: River Plate | ||||
| H | Emelec | - | Santa Fe | 2:1 (0:1) | ||
| R | Santa Fe | - | Emelec | 1:0 (1:0) | ||
| H: 24.09.2015 00:00 | R: 30.09.2015 02:00 | Sieger: Santa Fe | ||||
| H | Independiente | - | Club Olimpia | 1:0 (1:0) | ||
| R | Club Olimpia | - | Independiente | 0:0 (0:0) | ||
| H: 24.09.2015 02:15 | R: 01.10.2015 02:00 | Sieger: Independiente | ||||
| H | Athletico Paranaense | - | Brasília FC - DF | 1:0 (0:0) | ||
| R | Brasília FC - DF | - | Athletico Paranaense | 0:0 (0:0) | ||
| H: 24.09.2015 03:00 | R: 01.10.2015 03:00 | Sieger: Athletico Paranaense | ||||
| H | Sport Recife - PE | - | Huracán | 1:1 (0:0) | ||
| R | Huracán | - | Sport Recife - PE | 3:0 (0:0) | ||
| H: 24.09.2015 03:00 | R: 01.10.2015 03:10 | Sieger: Huracán | ||||
| H | Lanús | - | Defensor Sporting | 0:0 (0:0) | ||
| R | Defensor Sporting | - | Lanús | 5:3 (0:0, 0:0) i.E. | ||
| H: 25.09.2015 02:00 | R: 02.10.2015 02:00 | Sieger: Defensor Sporting | ||||
| H | Libertad | - | Chapecoense | 1:1 (0:1) | ||
| R | Chapecoense | - | Libertad | 5:3 (1:1, 1:1) i.E. | ||
| H: 25.09.2015 02:00 | R: 02.10.2015 02:00 | Sieger: Chapecoense | ||||
