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| 28.01.2018 | 12:00 | Real Betis B | - | Recreativo Huelva | 2:0 (1:0) | |
| 12:00 | Real Murcia | - | UD Melilla | 0:1 (0:0) | ||
| 12:00 | FC Jumilla | - | CF Villanovense | 0:0 (0:0) | ||
| 12:00 | UD Las Palmas B | - | Mérida AD | 2:0 (1:0) | ||
| 12:00 | Granada CF B | - | Córdoba CF B | 1:0 (0:0) | ||
| 17:00 | Extremadura UD | - | RB Linense | 0:2 (0:0) | ||
| 17:00 | Lorca Deportiva | - | Écija Balompié | 0:1 (0:0) | ||
| 17:00 | CD Badajoz | - | CD El Ejido 2012 | 3:0 (0:0) | ||
| 17:00 | FC Cartagena | - | UCAM Murcia CF | 3:2 (1:0) | ||
| 17:00 | San Fernando CD | - | Marbella FC | 1:3 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Cartagena | 23 | 13 | 6 | 4 | 34:24 | 10 | 45 |
| 2 |
|
Marbella FC | 23 | 12 | 5 | 6 | 33:21 | 12 | 41 |
| 3 |
|
Extremadura UD | 23 | 11 | 6 | 6 | 35:22 | 13 | 39 |
| 4 |
|
Real Murcia | 23 | 10 | 7 | 6 | 29:19 | 10 | 37 |
| 5 |
|
Granada CF B | 23 | 10 | 7 | 6 | 24:18 | 6 | 37 |
| 6 |
|
UD Melilla | 23 | 11 | 4 | 8 | 22:13 | 9 | 37 |
| 7 |
|
UCAM Murcia CF | 23 | 10 | 6 | 7 | 24:23 | 1 | 36 |
| 8 |
|
RB Linense | 23 | 9 | 7 | 7 | 32:22 | 10 | 34 |
| 9 |
|
Écija Balompié | 23 | 8 | 7 | 8 | 25:32 | -7 | 31 |
| 10 |
|
San Fernando CD | 23 | 8 | 6 | 9 | 30:29 | 1 | 30 |
| 11 |
|
CD Badajoz | 23 | 7 | 8 | 8 | 31:28 | 3 | 29 |
| 12 |
|
CD El Ejido 2012 | 23 | 7 | 8 | 8 | 33:35 | -2 | 29 |
| 13 |
|
Recreativo Huelva | 23 | 7 | 8 | 8 | 21:21 | 0 | 29 |
| 14 |
|
CF Villanovense | 23 | 6 | 10 | 7 | 16:22 | -6 | 28 |
| 15 |
|
Mérida AD | 23 | 6 | 8 | 9 | 21:26 | -5 | 26 |
| 16 |
|
Real Betis B | 23 | 6 | 7 | 10 | 28:38 | -10 | 25 |
| 17 |
|
FC Jumilla | 23 | 5 | 9 | 9 | 18:29 | -11 | 24 |
| 18 |
|
Córdoba CF B | 23 | 5 | 8 | 10 | 28:33 | -5 | 23 |
| 19 |
|
UD Las Palmas B | 23 | 6 | 5 | 12 | 26:32 | -6 | 23 |
| 20 |
|
Lorca Deportiva | 23 | 4 | 6 | 13 | 20:43 | -23 | 18 |
| Playoffs | |
| Playoffs | |
| Relegation | |
| Abstieg |
