 |
 |
|
| H | Deportivo Morón | - | Quilmes | 2:2 (1:1) | ||
| R | Quilmes | - | Deportivo Morón | 5:4 (1:1, 1:1) i.E. | ||
| H: 21.11.2021 23:15 | R: 27.11.2021 23:10 | Sieger: Quilmes | ||||
| H | Independiente Rivadavia | - | Almirante Brown | 1:1 (0:0) | ||
| R | Almirante Brown | - | Independiente Rivadavia | 1:0 (1:0) | ||
| H: 22.11.2021 21:00 | R: 29.11.2021 21:00 | Sieger: Almirante Brown | ||||
| H | San Martín de Tucumán | - | Ferro Carril Oeste | 1:3 (1:2) | ||
| R | Ferro Carril Oeste | - | San Martín de Tucumán | 0:1 (0:0) | ||
| H: 22.11.2021 23:05 | R: 30.11.2021 01:10 | Sieger: Ferro Carril Oeste | ||||
