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| H | Almirante Brown | - | Barracas Central | 0:0 (0:0) | ||
| R | Barracas Central | - | Almirante Brown | 3:2 (3:0) | ||
| H: 06.12.2021 21:00 | R: 13.12.2021 21:00 | Sieger: Barracas Central | ||||
| H | Ferro Carril Oeste | - | Quilmes | 1:1 (0:0) | ||
| R | Quilmes | - | Ferro Carril Oeste | 1:0 (0:0) | ||
| H: 07.12.2021 01:10 | R: 14.12.2021 01:10 | Sieger: Quilmes | ||||
