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| 04.11.2021 | 18:00 | VfL Wolfsburg | - | Hannover 96 | 3:1 (2:1) | |
| 06.11.2021 | 11:00 | FC St. Pauli | - | Erzgebirge Aue | 5:0 (2:0) | |
| 11:00 | Hamburger SV | - | Chemnitzer FC | 1:0 (1:0) | ||
| 11:00 | Holstein Kiel | - | FC Carl Zeiss Jena | 1:0 (0:0) | ||
| 11:00 | Werder Bremen | - | Hallescher FC | 5:0 (0:0) | ||
| 12:00 | Energie Cottbus | - | FC Viktoria 1889 Berlin | 2:1 (1:0) | ||
| 13:00 | Hertha Zehlendorf | - | Hansa Rostock | 3:1 (1:1) | ||
| 13:00 | Eintracht Braunschweig | - | 1. FC Union Berlin | 0:2 (0:1) | ||
| 11.12.2021 | 14:00 | Hertha BSC | - | Dynamo Dresden | 3:0 (0:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Hertha BSC | 10 | 10 | 0 | 0 | 34:2 | 32 | 30 |
| 2 |
|
FC St. Pauli | 10 | 7 | 1 | 2 | 27:6 | 21 | 22 |
| 3 |
|
VfL Wolfsburg | 10 | 6 | 3 | 1 | 23:11 | 12 | 21 |
| 4 |
|
Hamburger SV | 9 | 6 | 1 | 2 | 20:10 | 10 | 19 |
| 5 |
|
Chemnitzer FC | 10 | 6 | 1 | 3 | 14:14 | 0 | 19 |
| 6 |
|
1. FC Union Berlin | 10 | 6 | 0 | 4 | 14:10 | 4 | 18 |
| 7 |
|
Hannover 96 | 9 | 5 | 1 | 3 | 12:12 | 0 | 16 |
| 8 |
|
Dynamo Dresden | 9 | 5 | 0 | 4 | 18:11 | 7 | 15 |
| 9 |
|
Werder Bremen | 9 | 5 | 0 | 4 | 21:17 | 4 | 15 |
| 10 |
|
RB Leipzig | 9 | 4 | 1 | 4 | 12:13 | -1 | 13 |
| 11 |
|
FC Viktoria 1889 Berlin | 9 | 4 | 0 | 5 | 13:14 | -1 | 12 |
| 12 |
|
Hansa Rostock | 10 | 3 | 2 | 5 | 14:18 | -4 | 11 |
| 13 |
|
Holstein Kiel | 9 | 3 | 1 | 5 | 13:22 | -9 | 10 |
| 14 |
|
Energie Cottbus | 10 | 3 | 0 | 7 | 11:24 | -13 | 9 |
| 15 |
|
Eintracht Braunschweig | 9 | 2 | 2 | 5 | 8:15 | -7 | 8 |
| 16 |
|
Erzgebirge Aue | 9 | 2 | 2 | 5 | 6:15 | -9 | 8 |
| 17 |
|
Hertha Zehlendorf | 9 | 2 | 0 | 7 | 13:19 | -6 | 6 |
| 18 |
|
Hallescher FC | 10 | 1 | 2 | 7 | 8:35 | -27 | 5 |
| 19 |
|
FC Carl Zeiss Jena | 10 | 1 | 1 | 8 | 4:17 | -13 | 4 |
| Playoffs | |
| Abstieg |
