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| 21.01.2022 | 20:00 | RWDM Brussels FC | - | Lommel SK | 2:0 (1:0) | |
| 23.01.2022 | 16:00 | Excelsior Virton | - | Waasland-Beveren | 0:4 (0:2) | |
| 20:00 | Royal Excel Mouscron | - | Lierse Kempenzonen | 0:0 (0:0) | ||
| 09.02.2022 | 18:45 | KVC Westerlo | - | SK Deinze | 0:3 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KVC Westerlo | 17 | 11 | 4 | 2 | 32:17 | 15 | 37 |
| 2 |
|
Waasland-Beveren | 17 | 8 | 3 | 6 | 33:24 | 9 | 27 |
| 3 |
|
RWDM Brussels FC | 17 | 7 | 5 | 5 | 26:25 | 1 | 26 |
| 4 |
|
SK Deinze | 17 | 5 | 9 | 3 | 30:25 | 5 | 24 |
| 5 |
|
Royal Excel Mouscron | 17 | 5 | 5 | 7 | 22:28 | -6 | 20 |
| 6 |
|
Lierse Kempenzonen | 17 | 4 | 7 | 6 | 29:31 | -2 | 19 |
| 7 |
|
Lommel SK | 17 | 4 | 4 | 9 | 25:30 | -5 | 16 |
| 8 |
|
Excelsior Virton | 17 | 3 | 5 | 9 | 15:32 | -17 | 14 |
| Aufstieg | |
| Relegation | |
| Abstieg |
