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| H | Mamelodi Sundowns | - | Al Ahly SC | 5:0 (2:0) | ||
| R | Al Ahly SC | - | Mamelodi Sundowns | 1:0 (0:0) | ||
| H: 06.04.2019 15:00 | R: 13.04.2019 18:00 | Sieger: Mamelodi Sundowns | ||||
| H | Simba SC | - | TP Mazembe | 0:0 (0:0) | ||
| R | TP Mazembe | - | Simba SC | 4:1 (2:1) | ||
| H: 06.04.2019 15:00 | R: 13.04.2019 15:00 | Sieger: TP Mazembe | ||||
| H | Horoya AC | - | Wydad AC | 0:0 (0:0) | ||
| R | Wydad AC | - | Horoya AC | 5:0 (3:0) | ||
| H: 06.04.2019 18:00 | R: 13.04.2019 21:00 | Sieger: Wydad AC | ||||
| H | CS Constantine | - | Espérance de Tunis | 2:3 (0:1) | ||
| R | Espérance de Tunis | - | CS Constantine | 3:1 (2:0) | ||
| H: 06.04.2019 21:00 | R: 13.04.2019 21:00 | Sieger: Espérance de Tunis | ||||
