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| H | FC Schalke 04 | - | FC Porto | 1:0 (1:0) | ||
| R | FC Porto | - | FC Schalke 04 | 1:4 (0:0, 1:0, 1:0) i.E. | ||
| H: 19.02.2008 20:45 | R: 05.03.2008 20:45 | Sieger: FC Schalke 04 | ||||
| H | Liverpool FC | - | Inter | 2:0 (0:0) | ||
| R | Inter | - | Liverpool FC | 0:1 (0:0) | ||
| H: 19.02.2008 20:45 | R: 11.03.2008 20:45 | Sieger: Liverpool FC | ||||
| H | AS Roma | - | Real Madrid | 2:1 (1:1) | ||
| R | Real Madrid | - | AS Roma | 1:2 (0:0) | ||
| H: 19.02.2008 20:45 | R: 05.03.2008 20:45 | Sieger: AS Roma | ||||
| H | Olympiakos Piraeus | - | Chelsea FC | 0:0 (0:0) | ||
| R | Chelsea FC | - | Olympiakos Piraeus | 3:0 (2:0) | ||
| H: 19.02.2008 20:45 | R: 05.03.2008 20:45 | Sieger: Chelsea FC | ||||
| H | Celtic FC | - | FC Barcelona | 2:3 (2:1) | ||
| R | FC Barcelona | - | Celtic FC | 1:0 (1:0) | ||
| H: 20.02.2008 20:45 | R: 04.03.2008 20:45 | Sieger: FC Barcelona | ||||
| H | Olympique Lyon | - | Manchester United | 1:1 (0:0) | ||
| R | Manchester United | - | Olympique Lyon | 1:0 (1:0) | ||
| H: 20.02.2008 20:45 | R: 04.03.2008 20:45 | Sieger: Manchester United | ||||
| H | Arsenal FC | - | AC Milan | 0:0 (0:0) | ||
| R | AC Milan | - | Arsenal FC | 0:2 (0:0) | ||
| H: 20.02.2008 20:45 | R: 04.03.2008 20:45 | Sieger: Arsenal FC | ||||
| H | Fenerbahçe | - | Sevilla FC | 3:2 (1:1) | ||
| R | Sevilla FC | - | Fenerbahçe | 2:3 (3:1, 3:2, 3:2) i.E. | ||
| H: 20.02.2008 20:45 | R: 04.03.2008 20:45 | Sieger: Fenerbahçe | ||||
