 |
 |
|
|
| H | Malmö FF | - | Rangers FC | 2:1 (0:0) | ||
| R | Rangers FC | - | Malmö FF | 1:2 (1:0) | ||
| H: 03.08.2021 19:00 | R: 10.08.2021 21:00 | Sieger: Malmö FF | ||||
| H | AC Sparta Praha | - | AS Monaco | 0:2 (0:1) | ||
| R | AS Monaco | - | AC Sparta Praha | 3:1 (0:0) | ||
| H: 03.08.2021 19:00 | R: 10.08.2021 20:00 | Sieger: AS Monaco | ||||
| H | CFR Cluj | - | BSC Young Boys | 1:1 (1:0) | ||
| R | BSC Young Boys | - | CFR Cluj | 3:1 (3:1) | ||
| H: 03.08.2021 20:00 | R: 10.08.2021 20:30 | Sieger: BSC Young Boys | ||||
| H | PSV Eindhoven | - | FC Midtjylland | 3:0 (3:0) | ||
| R | FC Midtjylland | - | PSV Eindhoven | 0:1 (0:0) | ||
| H: 03.08.2021 20:00 | R: 10.08.2021 20:00 | Sieger: PSV Eindhoven | ||||
| H | KRC Genk | - | Shakhtar Donetsk | 1:2 (1:0) | ||
| R | Shakhtar Donetsk | - | KRC Genk | 2:1 (1:0) | ||
| H: 03.08.2021 20:00 | R: 10.08.2021 19:30 | Sieger: Shakhtar Donetsk | ||||
| H | Olympiakos Piraeus | - | PFC Ludogorets Razgrad | 1:1 (0:0) | ||
| R | PFC Ludogorets Razgrad | - | Olympiakos Piraeus | 4:1 (0:1, 2:2, 2:2) i.E. | ||
| H: 03.08.2021 21:00 | R: 10.08.2021 20:00 | Sieger: PFC Ludogorets Razgrad | ||||
| H | Crvena Zvezda | - | FC Sheriff | 1:1 (1:1) | ||
| R | FC Sheriff | - | Crvena Zvezda | 1:0 (1:0) | ||
| H: 03.08.2021 21:00 | R: 10.08.2021 19:00 | Sieger: FC Sheriff | ||||
| H | Spartak Moskva | - | SL Benfica | 0:2 (0:0) | ||
| R | SL Benfica | - | Spartak Moskva | 2:0 (0:0) | ||
| H: 04.08.2021 19:00 | R: 10.08.2021 21:00 | Sieger: SL Benfica | ||||
| H | Dinamo Zagreb | - | Legia Warszawa | 1:1 (0:0) | ||
| R | Legia Warszawa | - | Dinamo Zagreb | 0:1 (0:1) | ||
| H: 04.08.2021 20:00 | R: 10.08.2021 21:00 | Sieger: Dinamo Zagreb | ||||
| H | Ferencvárosi TC | - | Slavia Praha | 2:0 (1:0) | ||
| R | Slavia Praha | - | Ferencvárosi TC | 1:0 (1:0) | ||
| H: 04.08.2021 20:00 | R: 10.08.2021 19:00 | Sieger: Ferencvárosi TC | ||||
