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| H | América de Cali | - | Unión Magdalena | 1:2 (1:2) | ||
| R | Unión Magdalena | - | América de Cali | 2:1 (2:1) | ||
| H: 20.04.2022 22:30 | R: 12.05.2022 16:00 | Sieger: Unión Magdalena | ||||
| H | Independiente Medellín | - | Tigres FC | 1:0 (1:0) | ||
| R | Tigres FC | - | Independiente Medellín | 1:2 (1:0) | ||
| H: 20.04.2022 22:30 | R: 11.05.2022 21:00 | Sieger: Independiente Medellín | ||||
| H | La Equidad | - | Atlético Bucaramanga | 2:0 (2:0) | ||
| R | Atlético Bucaramanga | - | La Equidad | 0:0 (0:0) | ||
| H: 20.04.2022 23:00 | R: 12.05.2022 00:00 | Sieger: La Equidad | ||||
| H | Atlético Junior | - | Santa Fe | 2:1 (1:1) | ||
| R | Santa Fe | - | Atlético Junior | 0:1 (0:0) | ||
| H: 21.04.2022 01:00 | R: 12.05.2022 03:10 | Sieger: Atlético Junior | ||||
| H | Deportes Tolima | - | Deportivo Pereira | 3:2 (2:2) | ||
| R | Deportivo Pereira | - | Deportes Tolima | 1:1 (0:1) | ||
| H: 21.04.2022 02:30 | R: 12.05.2022 02:00 | Sieger: Deportes Tolima | ||||
| H | Atlético Nacional | - | Once Caldas | 3:0 (2:0) | ||
| R | Once Caldas | - | Atlético Nacional | 1:2 (0:1) | ||
| H: 21.04.2022 03:00 | R: 12.05.2022 01:00 | Sieger: Atlético Nacional | ||||
| H | Deportivo Cali | - | Fortaleza FC | 1:3 (1:1) | ||
| R | Fortaleza FC | - | Deportivo Cali | 1:1 (0:1) | ||
| H: 21.04.2022 03:15 | R: 13.05.2022 03:00 | Sieger: Fortaleza FC | ||||
| H | Millonarios | - | Jaguares de Córdoba | 3:0 (2:0) | ||
| R | Jaguares de Córdoba | - | Millonarios | 1:1 (1:1) | ||
| H: 22.04.2022 03:00 | R: 12.05.2022 01:00 | Sieger: Millonarios | ||||
