H LD Alajuelense - Atlanta United FC -:-
R Atlanta United FC - LD Alajuelense -:-
H: 07.04.2021 R: 14.04.2021
H Arcahaie FC - Cruz Azul -:-
R Cruz Azul - Arcahaie FC -:-
H: 07.04.2021 R: 14.04.2021
H Deportivo Saprissa - Philadelphia Union -:-
R Philadelphia Union - Deportivo Saprissa -:-
H: 07.04.2021 R: 14.04.2021
H Marathón - Portland Timbers -:-
R Portland Timbers - Marathón -:-
H: 07.04.2021 R: 14.04.2021
H CD Pantoja - CF Monterrey -:-
R CF Monterrey - CD Pantoja -:-
H: 07.04.2021 R: 14.04.2021
H Real Estelí - Columbus Crew -:-
R Columbus Crew - Real Estelí -:-
H: 07.04.2021 R: 14.04.2021
H Olimpia - CF América -:-
R CF América - Olimpia -:-
H: 07.04.2021 R: 14.04.2021
H Club León - Forge / Toronto -:-
R Forge / Toronto - Club León -:-
H: 07.04.2021 R: 14.04.2021