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| H | Toronto FC | - | Motagua | 1:0 | ||
| R | Motagua | - | Toronto FC | 2:2 | ||
| H: 28.07.2010 02:00 | R: 04.08.2010 02:00 | Sieger: Toronto FC | ||||
| H | San Juan Jabloteh | - | Santos Laguna | 0:1 | ||
| R | Santos Laguna | - | San Juan Jabloteh | 5:0 | ||
| H: 28.07.2010 02:00 | R: 05.08.2010 04:00 | Sieger: Santos Laguna | ||||
| H | Los Angeles Galaxy | - | Puerto Rico Islanders | 1:4 | ||
| R | Puerto Rico Islanders | - | Los Angeles Galaxy | 1:2 | ||
| H: 28.07.2010 04:00 | R: 05.08.2010 02:00 | Sieger: Puerto Rico Islanders | ||||
| H | San Francisco FC | - | Cruz Azul | 2:3 | ||
| R | Cruz Azul | - | San Francisco FC | 6:0 | ||
| H: 28.07.2010 04:35 | R: 04.08.2010 02:00 | Sieger: Cruz Azul | ||||
| H | Tauro FC | - | Marathón | 0:3 | ||
| R | Marathón | - | Tauro FC | 1:2 | ||
| H: 29.07.2010 02:00 | R: 05.08.2010 04:00 | Sieger: Marathón | ||||
| H | Brujas de Escazú | - | Joe Public FC | 2:2 | ||
| R | Joe Public FC | - | Brujas de Escazú | 4:2 | ||
| H: 29.07.2010 02:00 | R: 06.08.2010 02:00 | Sieger: Joe Public FC | ||||
| H | Seattle Sounders | - | Isidro Metapán | 1:0 | ||
| R | Isidro Metapán | - | Seattle Sounders | 1:1 | ||
| H: 29.07.2010 02:00 | R: 04.08.2010 04:00 | Sieger: Seattle Sounders | ||||
| H | FAS | - | Xelaju MC | 1:1 | ||
| R | Xelaju MC | - | FAS | 0:2 | ||
| H: 30.07.2010 04:00 | R: 06.08.2010 04:00 | Sieger: FAS | ||||
