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| H | Alianza | - | LD Alajuelense | 0:1 (0:1) | ||
| R | LD Alajuelense | - | Alianza | 2:0 (1:0) | ||
| H: 08.09.2022 04:00 | R: 14.09.2022 04:00 | Sieger: LD Alajuelense | ||||
| H | Motagua | - | Tauro FC | 0:0 (0:0) | ||
| R | Tauro FC | - | Motagua | 4:5 (0:0, 0:0) i.E. | ||
| H: 09.09.2022 00:00 | R: 15.09.2022 04:00 | Sieger: Motagua | ||||
| H | Real España | - | CS Herediano | 3:1 (0:0) | ||
| R | CS Herediano | - | Real España | 1:1 (0:1) | ||
| H: 09.09.2022 02:00 | R: 16.09.2022 02:00 | Sieger: Real España | ||||
| H | Diriangén FC | - | Olimpia | 0:4 (0:3) | ||
| R | Olimpia | - | Diriangén FC | 3:1 (0:1) | ||
| H: 09.09.2022 04:00 | R: 16.09.2022 04:15 | Sieger: Olimpia | ||||
