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| H | CD Magallanes | - | Independiente Medellín | 1:1 (0:0) | ||
| R | Independiente Medellín | - | CD Magallanes | 2:0 (2:0) | ||
| H: 08.03.2023 23:00 | R: 16.03.2023 01:00 | Sieger: Independiente Medellín | ||||
| H | Millonarios | - | Atlético Mineiro | 1:1 (1:0) | ||
| R | Atlético Mineiro | - | Millonarios | 3:1 (0:0) | ||
| H: 09.03.2023 01:30 | R: 16.03.2023 01:30 | Sieger: Atlético Mineiro | ||||
| H | Fortaleza | - | Cerro Porteño | 0:1 (0:1) | ||
| R | Cerro Porteño | - | Fortaleza | 2:1 (1:0) | ||
| H: 09.03.2023 23:00 | R: 16.03.2023 23:00 | Sieger: Cerro Porteño | ||||
| H | Huracán | - | Sporting Cristal | 0:0 (0:0) | ||
| R | Sporting Cristal | - | Huracán | 1:0 (0:0) | ||
| H: 10.03.2023 01:00 | R: 17.03.2023 01:00 | Sieger: Sporting Cristal | ||||
