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| H | Ermis Aradippou | - | Enosis Neon Paralimni | 1:1 | ||
| R | Enosis Neon Paralimni | - | Ermis Aradippou | 5:0 (2:0) | ||
| H: 12.01.2022 13:30 | R: 19.01.2022 14:30 | Sieger: Enosis Neon Paralimni | ||||
| H | Onisilos Sotiras | - | Karmiotissa Polemidion | 4:3 | ||
| R | Karmiotissa Polemidion | - | Onisilos Sotiras | 0:1 (0:1) | ||
| H: 12.01.2022 13:30 | R: 19.01.2022 12:30 | Sieger: Onisilos Sotiras | ||||
| H | AEK Larnaca | - | PAEEK | 1:1 (0:0) | ||
| R | PAEEK | - | AEK Larnaca | 2:2 | ||
| H: 18.01.2022 18:00 | R: 02.03.2022 18:00 | Sieger: AEK Larnaca | ||||
| H | Paphos FC | - | Anorthosis Famagusta | 1:3 (1:0) | ||
| R | Anorthosis Famagusta | - | Paphos FC | 0:0 | ||
| H: 19.01.2022 15:30 | R: 03.02.2022 17:00 | Sieger: Anorthosis Famagusta | ||||
| H | APOEL Nikosia | - | Olympiakos Nikosia | 2:1 (1:1) | ||
| R | Olympiakos Nikosia | - | APOEL Nikosia | 0:4 (0:1) | ||
| H: 19.01.2022 18:00 | R: 02.02.2022 17:00 | Sieger: APOEL Nikosia | ||||
| H | P.O. Xylotymbou | - | Omonia Nikosia | 0:5 (0:1) | ||
| R | Omonia Nikosia | - | P.O. Xylotymbou | 2:1 (1:1) | ||
| H: 20.01.2022 16:00 | R: 01.02.2022 16:00 | Sieger: Omonia Nikosia | ||||
| H | Ethnikos Achna | - | Doxa Katokopias | 3:1 (1:0) | ||
| R | Doxa Katokopias | - | Ethnikos Achna | 0:0 | ||
| H: 26.01.2022 15:00 | R: 03.02.2022 16:00 | Sieger: Ethnikos Achna | ||||
| H | Apollon Limassol | - | AEL Limassol | 1:0 (0:0) | ||
| R | AEL Limassol | - | Apollon Limassol | 2:0 n.V. | ||
| H: 26.01.2022 17:00 | R: 02.03.2022 18:00 | Sieger: AEL Limassol | ||||
