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| H | Orense SC | - | Delfin SC | 1:0 (1:0) | ||
| R | Delfin SC | - | Orense SC | 3:0 (1:0, 2:1, 2:1) i.E. | ||
| H: 19.08.2022 18:00 | R: 26.08.2022 16:00 | Sieger: Delfin SC | ||||
| H | Manta FC | - | Emelec | 1:2 (1:0) | ||
| R | Emelec | - | Manta FC | 8:6 (0:0, 0:1, 0:1) i.E. | ||
| H: 19.08.2022 20:00 | R: 27.08.2022 22:30 | Sieger: Emelec | ||||
| H | Macará | - | Cumbayá | 2:2 (1:1) | ||
| R | Cumbayá | - | Macará | 5:4 (0:0, 0:0, 0:0) i.E. | ||
| H: 20.08.2022 17:00 | R: 27.08.2022 16:00 | Sieger: Cumbayá | ||||
| H | Aucas | - | Mushuc Runa | 4:3 (4:2) | ||
| R | Mushuc Runa | - | Aucas | 4:2 (1:0, 2:1, 2:1) i.E. | ||
| H: 20.08.2022 18:00 | R: 27.08.2022 16:30 | Sieger: Mushuc Runa | ||||
| H | Universidad Catolica | - | Barcelona | 1:1 (1:1) | ||
| R | Barcelona | - | Universidad Catolica | 5:1 (3:1) | ||
| H: 20.08.2022 18:00 | R: 27.08.2022 20:00 | Sieger: Barcelona | ||||
| H | 9 de Octubre | - | Independiente del Valle | 1:4 (0:3) | ||
| R | Independiente del Valle | - | 9 de Octubre | 3:0 Wert. | ||
| H: 20.08.2022 19:15 | R: 27.08.2022 17:00 | Sieger: Independiente del Valle | ||||
| H | Olmedo | - | Búhos ULVR | 0:2 (0:0) | ||
| R | Búhos ULVR | - | Olmedo | 9:0 (4:0) | ||
| H: 21.08.2022 19:00 | R: 27.08.2022 18:00 | Sieger: Búhos ULVR | ||||
| H | LDU Quito | - | El Nacional | 3:2 (1:1) | ||
| R | El Nacional | - | LDU Quito | 1:1 (0:1) | ||
| H: 21.08.2022 22:15 | R: 27.08.2022 18:30 | Sieger: LDU Quito | ||||
