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| H | Cumbayá | - | Emelec | 1:5 (0:1) | ||
| R | Emelec | - | Cumbayá | 7:1 (4:0) | ||
| H: 02.09.2022 19:00 | R: 10.09.2022 21:30 | Sieger: Emelec | ||||
| H | Mushuc Runa | - | Independiente del Valle | 2:3 (0:1) | ||
| R | Independiente del Valle | - | Mushuc Runa | 6:2 (1:1) | ||
| H: 03.09.2022 16:30 | R: 10.09.2022 16:30 | Sieger: Independiente del Valle | ||||
| H | Barcelona | - | Delfin SC | 3:2 (1:1) | ||
| R | Delfin SC | - | Barcelona | 0:3 (0:1) | ||
| H: 03.09.2022 18:00 | R: 09.09.2022 16:00 | Sieger: Barcelona | ||||
| H | LDU Quito | - | Búhos ULVR | 1:0 (0:0) | ||
| R | Búhos ULVR | - | LDU Quito | 9:8 (2:0, 2:1, 2:1) i.E. | ||
| H: 03.09.2022 18:15 | R: 10.09.2022 19:00 | Sieger: Búhos ULVR | ||||
