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| 04.03.2006 | 18:00 | CD Tenerife | - | CD Castellón | 1:1 (1:0) | |
| 18:30 | UE Lleida | - | Elche CF | 0:0 (0:0) | ||
| 18:30 | Racing Ferrol | - | Real Murcia | 2:2 (2:1) | ||
| 18:30 | Sporting Gijón | - | UD Almería | 1:0 (1:0) | ||
| 05.03.2006 | 12:00 | Lorca Deportiva | - | Recreativo Huelva | 2:1 (2:1) | |
| 17:00 | Ciudad de Murcia | - | CD Numancia | 0:1 (0:1) | ||
| 17:00 | Polideportivo Ejido | - | Albacete | 2:0 (1:0) | ||
| 17:00 | Levante UD | - | Gimnàstic de Tarragona | 1:1 (1:0) | ||
| 17:00 | SD Eibar | - | Atlético Malagueño | 1:1 (1:0) | ||
| 17:30 | Real Valladolid | - | Real Madrid Castilla | 1:0 (0:0) | ||
| 05.04.2006 | 21:00 | Hércules CF | - | Xerez CD | 0:3 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Xerez CD | 27 | 13 | 9 | 5 | 44:27 | 17 | 48 |
| 2 |
|
Recreativo Huelva | 27 | 13 | 9 | 5 | 36:22 | 14 | 48 |
| 3 |
|
Lorca Deportiva | 27 | 13 | 7 | 7 | 38:24 | 14 | 46 |
| 4 |
|
Levante UD | 27 | 12 | 10 | 5 | 36:26 | 10 | 46 |
| 5 |
|
Gimnàstic de Tarragona | 27 | 14 | 4 | 9 | 29:26 | 3 | 46 |
| 6 |
|
UD Almería | 27 | 12 | 6 | 9 | 32:24 | 8 | 42 |
| 7 |
|
CD Numancia | 27 | 10 | 9 | 8 | 26:32 | -6 | 39 |
| 8 |
|
Real Valladolid | 27 | 9 | 11 | 7 | 36:31 | 5 | 38 |
| 9 |
|
Ciudad de Murcia | 27 | 10 | 8 | 9 | 31:31 | 0 | 38 |
| 10 |
|
Albacete | 27 | 10 | 7 | 10 | 27:35 | -8 | 37 |
| 11 |
|
Real Madrid Castilla | 27 | 10 | 6 | 11 | 35:30 | 5 | 36 |
| 12 |
|
Sporting Gijón | 27 | 8 | 12 | 7 | 27:22 | 5 | 36 |
| 13 |
|
Elche CF | 27 | 9 | 8 | 10 | 32:37 | -5 | 35 |
| 14 |
|
Real Murcia | 27 | 8 | 10 | 9 | 25:25 | 0 | 34 |
| 15 |
|
UE Lleida | 27 | 9 | 6 | 12 | 26:27 | -1 | 33 |
| 16 |
|
Polideportivo Ejido | 27 | 9 | 6 | 12 | 29:33 | -4 | 33 |
| 17 |
|
CD Tenerife | 27 | 8 | 7 | 12 | 33:40 | -7 | 31 |
| 18 |
|
Hércules CF | 27 | 7 | 9 | 11 | 26:34 | -8 | 30 |
| 19 |
|
Racing Ferrol | 27 | 5 | 12 | 10 | 31:38 | -7 | 27 |
| 20 |
|
CD Castellón | 27 | 6 | 8 | 13 | 25:36 | -11 | 26 |
| 21 |
|
SD Eibar | 27 | 4 | 13 | 10 | 19:29 | -10 | 25 |
| 22 |
|
Atlético Malagueño | 27 | 5 | 9 | 13 | 20:34 | -14 | 24 |
