H Dinamo Tbilisi / Maccabi Haifa - HB Tórshavn / Budućnost Podgorica -:-
R HB Tórshavn / Budućnost Podgorica - Dinamo Tbilisi / Maccabi Haifa -:-
H: 05.08.2021 R: 12.08.2021
H Linfield / Banja Luka - Shakhter Soligorsk / Fola Esch -:-
R Shakhter Soligorsk / Fola Esch - Linfield / Banja Luka -:-
H: 05.08.2021 R: 12.08.2021
H Shamrock Rovers - Teuta / IC d'Escaldes -:-
R Teuta / IC d'Escaldes - Shamrock Rovers -:-
H: 05.08.2021 R: 12.08.2021
H Riga FC / Shkëndija - Folgore / Hibernians -:-
R Folgore / Hibernians - Riga FC / Shkëndija -:-
H: 05.08.2021 R: 12.08.2021
H Prishtina / Connah's Quay - Valur / Bodø/Glimt -:-
R Valur / Bodø/Glimt - Prishtina / Connah's Quay -:-
H: 05.08.2021 R: 12.08.2021
H Dinamo Batumi / BATE Borisov - Petrocub / Sivasspor -:-
R Petrocub / Sivasspor - Dinamo Batumi / BATE Borisov -:-
H: 05.08.2021 R: 12.08.2021
H Kuopion/ Vorskla Poltava - Astana / Aris Saloniki -:-
R Astana / Aris Saloniki - Kuopion/ Vorskla Poltava -:-
H: 05.08.2021 R: 12.08.2021
H Sochi / Keşlə - Partizan / Dunajská Streda -:-
R Partizan / Dunajská Streda - Sochi / Keşlə -:-
H: 05.08.2021 R: 12.08.2021
H Shkupi / Santa Clara - Ljubljana / Birkirkara -:-
R Ljubljana / Birkirkara - Shkupi / Santa Clara -:-
H: 05.08.2021 R: 12.08.2021
H Újpest / Vaduz - FC Basel / Partizani -:-
R FC Basel / Partizani - Újpest / Vaduz -:-
H: 05.08.2021 R: 12.08.2021
H Kolos Kovalivka - FCSB / Shakter Karaganda -:-
R FCSB / Shakter Karaganda - Kolos Kovalivka -:-
H: 05.08.2021 R: 12.08.2021
H Elfsborg / Milsami - V. Mostar / AEK -:-
R V. Mostar / AEK - Elfsborg / Milsami -:-
H: 05.08.2021 R: 12.08.2021
H Paços de Ferreira - Larne / Aarhus -:-
R Larne / Aarhus - Paços de Ferreira -:-
H: 05.08.2021 R: 12.08.2021
H FC Luzern - Drita / Feyenoord -:-
R Drita / Feyenoord - FC Luzern -:-
H: 05.08.2021 R: 12.08.2021
H Rīgas FS / Puskás - Gent / Vålerenga -:-
R Gent / Vålerenga - Rīgas FS / Puskás -:-
H: 05.08.2021 R: 12.08.2021
H Hibernian / Santa Coloma - Gżira / Rijeka -:-
R Gżira / Rijeka - Hibernian / Santa Coloma -:-
H: 05.08.2021 R: 12.08.2021
H Austria Wien / Breiðablik - Aberdeen / Häcken -:-
R Aberdeen / Häcken - Austria Wien / Breiðablik -:-
H: 05.08.2021 R: 12.08.2021
H Trabzonspor - Molde / Servette -:-
R Molde / Servette - Trabzonspor -:-
H: 05.08.2021 R: 12.08.2021
H Dudelange / Bohemians - PAOK Saloniki -:-
R PAOK Saloniki - Dudelange / Bohemians -:-
H: 05.08.2021 R: 12.08.2021
H Kauno Žalgiris / New Saints - Vikt. Plzeň / Dinamo Brest -:-
R Vikt. Plzeň / Dinamo Brest - Kauno Žalgiris / New Saints -:-
H: 05.08.2021 R: 12.08.2021
H Sūduva / Raków Częstochowa - Rubin Kazan -:-
R Rubin Kazan - Sūduva / Raków Częstochowa -:-
H: 05.08.2021 R: 12.08.2021
H Lok. Plovdiv / Slovácko - København / Torpedo-B. Zhodino -:-
R København / Torpedo-B. Zhodino - Lok. Plovdiv / Slovácko -:-
H: 05.08.2021 R: 12.08.2021
H Hajduk Split / Tobyl Kostanay - Apollon Limassol / Žilina -:-
R Apollon Limassol / Žilina - Hajduk Split / Tobyl Kostanay -:-
H: 05.08.2021 R: 12.08.2021
H CSKA Sofia / Liepāja - Pogoń Szczecin / Osijek -:-
R Pogoń Szczecin / Osijek - CSKA Sofia / Liepāja -:-
H: 05.08.2021 R: 12.08.2021
H Panevėžys / Vojvodina - LASK -:-
R LASK - Panevėžys / Vojvodina -:-
H: 05.08.2021 R: 12.08.2021
H AEL Limassol / Vllaznia - Qarabağ / Ashdod -:-
R Qarabağ / Ashdod - AEL Limassol / Vllaznia -:-
H: 05.08.2021 R: 12.08.2021
H Spartak Trnava / Sepsi OSK - Sutjeska / Maccabi Tel Aviv -:-
R Sutjeska / Maccabi Tel Aviv - Spartak Trnava / Sepsi OSK -:-
H: 05.08.2021 R: 12.08.2021
H Hafnarfjörður / Rosenborg - Domžale / Honka -:-
R Domžale / Honka - Hafnarfjörður / Rosenborg -:-
H: 05.08.2021 R: 12.08.2021
H Laçi / U. Craiova - RSC Anderlecht -:-
R RSC Anderlecht - Laçi / U. Craiova -:-
H: 05.08.2021 R: 12.08.2021
H Vitesse - Dundalk / Levadia -:-
R Dundalk / Levadia - Vitesse -:-
H: 05.08.2021 R: 12.08.2021