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| H | Sporting Braga | - | Shakhtar Donetsk | 1:2 (0:1) | ||
| R | Shakhtar Donetsk | - | Sporting Braga | 4:0 (2:0) | ||
| H: 07.04.2016 21:05 | R: 14.04.2016 21:05 | Sieger: Shakhtar Donetsk | ||||
| H | Villarreal CF | - | AC Sparta Praha | 2:1 (1:1) | ||
| R | AC Sparta Praha | - | Villarreal CF | 2:4 (0:3) | ||
| H: 07.04.2016 21:05 | R: 14.04.2016 21:05 | Sieger: Villarreal CF | ||||
| H | Athletic Bilbao | - | Sevilla FC | 1:2 (0:0) | ||
| R | Sevilla FC | - | Athletic Bilbao | 5:4 (0:0, 1:2, 1:2) i.E. | ||
| H: 07.04.2016 21:05 | R: 14.04.2016 21:05 | Sieger: Sevilla FC | ||||
| H | Borussia Dortmund | - | Liverpool FC | 1:1 (0:1) | ||
| R | Liverpool FC | - | Borussia Dortmund | 4:3 (0:2) | ||
| H: 07.04.2016 21:05 | R: 14.04.2016 21:05 | Sieger: Liverpool FC | ||||
