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| 11.03.2022 | 19:00 | FC Bastia-Borgo | - | US Orléans | 2:2 (1:1) | |
| 19:00 | FC Sète | - | CS Sedan | 1:1 (0:0) | ||
| 19:00 | FC Villefranche Beaujolais | - | FC Annecy | 1:2 (0:0) | ||
| 19:00 | Le Mans FC | - | US Boulogne | 1:0 (1:0) | ||
| 19:00 | SO Cholet | - | Red Star FC | 0:1 (0:1) | ||
| 19:00 | Stade Briochin | - | FC Bourg-Péronnas | 1:0 (0:0) | ||
| 19:00 | US Avranches | - | FC Chambly | 1:0 (0:0) | ||
| 19:00 | US Créteil-Lusitanos | - | US Concarneau | 2:2 (2:1) | ||
| 14.03.2022 | 18:45 | LB Châteauroux | - | Stade Lavallois | 1:1 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Stade Lavallois | 25 | 15 | 4 | 6 | 32:21 | 11 | 49 |
| 2 |
|
US Concarneau | 25 | 13 | 8 | 4 | 34:18 | 16 | 47 |
| 3 |
|
FC Annecy | 25 | 12 | 8 | 5 | 35:22 | 13 | 44 |
| 4 |
|
FC Bourg-Péronnas | 25 | 12 | 7 | 6 | 43:25 | 18 | 43 |
| 5 |
|
FC Villefranche Beaujolais | 25 | 12 | 7 | 6 | 29:20 | 9 | 43 |
| 6 |
|
Le Mans FC | 25 | 12 | 6 | 7 | 26:20 | 6 | 42 |
| 7 |
|
LB Châteauroux | 25 | 11 | 8 | 6 | 31:21 | 10 | 41 |
| 8 |
|
CS Sedan | 25 | 10 | 9 | 6 | 31:25 | 6 | 39 |
| 9 |
|
Stade Briochin | 25 | 9 | 8 | 8 | 27:23 | 4 | 35 |
| 10 |
|
US Orléans | 25 | 8 | 9 | 8 | 28:27 | 1 | 33 |
| 11 |
|
Red Star FC | 25 | 10 | 3 | 12 | 40:36 | 4 | 32 |
| 12 |
|
SO Cholet | 25 | 9 | 5 | 11 | 38:46 | -8 | 32 |
| 13 |
|
US Avranches | 25 | 9 | 5 | 11 | 24:39 | -15 | 32 |
| 14 |
|
FC Sète | 25 | 7 | 5 | 13 | 27:33 | -6 | 26 |
| 15 |
|
FC Chambly | 25 | 5 | 6 | 14 | 29:46 | -17 | 21 |
| 16 |
|
FC Bastia-Borgo | 25 | 4 | 8 | 13 | 30:46 | -16 | 20 |
| 17 |
|
US Créteil-Lusitanos | 25 | 5 | 5 | 15 | 27:45 | -18 | 20 |
| 18 |
|
US Boulogne | 25 | 3 | 7 | 15 | 23:41 | -18 | 15 |
| Aufstieg | |
| Relegation | |
| Abstieg |
