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| H | Lobos UPNFM | - | Honduras Progreso | 3:2 (2:1) | ||
| R | Honduras Progreso | - | Lobos UPNFM | 4:0 (1:0) | ||
| H: 02.05.2021 01:00 | R: 06.05.2021 03:00 | Sieger: Honduras Progreso | ||||
| H | Vida | - | Motagua | 1:1 (0:0) | ||
| R | Motagua | - | Vida | 3:0 (0:0) | ||
| H: 02.05.2021 23:06 | R: 05.05.2021 03:00 | Sieger: Motagua | ||||
