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| 27.11.2021 | 14:30 | Calcio Catania | - | Potenza | annull. | |
| 17:30 | Campobasso | - | Virtus Francavilla | 2:2 (1:2) | ||
| 17:30 | SSC Bari | - | Latina Calcio | 3:1 (1:0) | ||
| 21:00 | SS Monopoli 1966 | - | Paganese Calcio | 1:0 (0:0) | ||
| 28.11.2021 | 14:30 | ACR Messina | - | Fidelis Andria | 2:3 (1:2) | |
| 14:30 | Foggia Calcio | - | Vibonese Calcio | 5:2 (4:0) | ||
| 14:30 | Monterosi FC | - | US Catanzaro | 1:1 (1:1) | ||
| 14:30 | AZ Picerno | - | Palermo FC | 1:0 (1:0) | ||
| 14:30 | FC Turris | - | US Avellino | 1:2 (1:2) | ||
| 29.11.2021 | 21:00 | SS Juve Stabia | - | Taranto FC | 3:2 (2:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSC Bari | 15 | 10 | 3 | 2 | 28:12 | 16 | 33 |
| 2 |
|
Palermo FC | 16 | 8 | 5 | 3 | 23:12 | 11 | 29 |
| 3 |
|
SS Monopoli 1966 | 15 | 8 | 3 | 4 | 17:11 | 6 | 27 |
| 4 |
|
US Avellino | 15 | 6 | 8 | 1 | 16:9 | 7 | 26 |
| 5 |
|
Foggia Calcio | 15 | 6 | 7 | 2 | 25:15 | 10 | 25 |
| 6 |
|
FC Turris | 15 | 8 | 1 | 6 | 26:18 | 8 | 25 |
| 7 |
|
US Catanzaro | 15 | 6 | 6 | 3 | 20:10 | 10 | 24 |
| 8 |
|
Virtus Francavilla | 15 | 7 | 2 | 6 | 17:14 | 3 | 23 |
| 9 |
|
SS Juve Stabia | 15 | 5 | 7 | 3 | 16:13 | 3 | 20 |
| 10 |
|
Taranto FC | 15 | 5 | 5 | 5 | 15:16 | -1 | 20 |
| 11 |
|
AZ Picerno | 15 | 5 | 5 | 5 | 12:15 | -3 | 20 |
| 12 |
|
Latina Calcio | 16 | 5 | 2 | 9 | 17:22 | -5 | 17 |
| 13 |
|
Campobasso | 15 | 4 | 5 | 6 | 19:26 | -7 | 17 |
| 14 |
|
Monterosi FC | 15 | 3 | 7 | 5 | 13:20 | -7 | 16 |
| 15 |
|
Fidelis Andria | 15 | 4 | 3 | 8 | 13:23 | -10 | 15 |
| 16 |
|
Potenza | 15 | 3 | 5 | 7 | 14:20 | -6 | 14 |
| 17 |
|
Paganese Calcio | 15 | 4 | 2 | 9 | 12:25 | -13 | 14 |
| 18 |
|
ACR Messina | 16 | 3 | 3 | 10 | 17:27 | -10 | 12 |
| 19 |
|
Vibonese Calcio | 15 | 1 | 7 | 7 | 10:22 | -12 | 10 |
| 20 |
|
Calcio Catania | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
|
# Calcio Catania ging im Frühjahr 2022 bankrott und wurde vom professionellen Fußball ausgeschlossen. Alle Saisonspiele des Vereins wurden annulliert. |
