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| 23.04.2022 | 15:00 | Cascina | - | Pro Livorno Sorgenti | 2:0 | |
| 15:00 | Follonica Gavorrano | - | Badesse Calcio | 1:0 | ||
| 15:00 | FC Rieti | - | SC Trestina | 2:1 | ||
| 15:00 | San Donato Tavarnelle | - | US Pianese | 0:2 | ||
| 15:00 | SSD Tiferno Lerchi | - | US Poggibonsi | 1:4 | ||
| 24.04.2022 | 15:00 | Foligno Calcio | - | Virtus Flaminia | 1:2 | |
| 15:00 | Montespaccato | - | Unipomezia Virtus | 2:0 | ||
| 15:00 | AC Sangiovannese | - | ASD Cannara | 2:2 | ||
| 15:00 | US Arezzo | - | Scandicci Calcio | 2:0 |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
San Donato Tavarnelle | 30 | 22 | 3 | 5 | 81:29 | 52 | 69 |
| 2 |
|
US Poggibonsi | 30 | 21 | 4 | 5 | 50:23 | 27 | 67 |
| 3 |
|
US Arezzo | 30 | 16 | 9 | 5 | 58:39 | 19 | 57 |
| 4 |
|
Follonica Gavorrano | 30 | 15 | 9 | 6 | 51:25 | 26 | 54 |
| 5 |
|
US Pianese | 30 | 14 | 7 | 9 | 48:36 | 12 | 49 |
| 6 |
|
Badesse Calcio | 30 | 13 | 8 | 9 | 40:37 | 3 | 47 |
| 7 |
|
SC Trestina | 30 | 12 | 10 | 8 | 44:32 | 12 | 46 |
| 8 |
|
Virtus Flaminia | 30 | 12 | 7 | 11 | 44:43 | 1 | 43 |
| 9 |
|
SSD Tiferno Lerchi | 30 | 10 | 10 | 10 | 33:41 | -8 | 40 |
| 10 |
|
Scandicci Calcio | 30 | 10 | 8 | 12 | 32:39 | -7 | 38 |
| 11 |
|
Montespaccato | 30 | 10 | 7 | 13 | 36:38 | -2 | 37 |
| 12 |
|
Cascina | 30 | 9 | 7 | 14 | 32:35 | -3 | 34 |
| 13 |
|
FC Rieti | 30 | 9 | 7 | 14 | 35:49 | -14 | 34 |
| 14 |
|
AC Sangiovannese | 30 | 7 | 12 | 11 | 33:38 | -5 | 33 |
| 15 |
|
Foligno Calcio | 30 | 7 | 7 | 16 | 38:59 | -21 | 28 |
| 16 |
|
Unipomezia Virtus | 30 | 7 | 6 | 17 | 33:59 | -26 | 27 |
| 17 |
|
ASD Cannara | 30 | 5 | 8 | 17 | 25:45 | -20 | 23 |
| 18 |
|
Pro Livorno Sorgenti | 30 | 4 | 5 | 21 | 28:74 | -46 | 17 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
