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| H | Pumas UNAM | - | CF Monterrey | 1:2 (0:0) | ||
| R | CF Monterrey | - | Pumas UNAM | 3:0 (2:0) | ||
| H: 24.04.2019 23:00 | R: 28.04.2019 04:06 | Sieger: CF Monterrey | ||||
| H | Atlas Guadalajara | - | CF Pachuca | 0:1 (0:0) | ||
| R | CF Pachuca | - | Atlas Guadalajara | 1:1 (0:0) | ||
| H: 26.04.2019 00:00 | R: 30.04.2019 02:00 | Sieger: CF Pachuca | ||||
| H | Puebla FC | - | UANL Tigres | 1:2 (0:0) | ||
| R | UANL Tigres | - | Puebla FC | 2:0 (0:0) | ||
| H: 26.04.2019 02:00 | R: 30.04.2019 03:00 | Sieger: UANL Tigres | ||||
| H | Club León | - | CF América | 0:1 (0:0) | ||
| R | CF América | - | Club León | 1:1 (0:1) | ||
| H: 26.04.2019 04:00 | R: 28.04.2019 23:00 | Sieger: CF América | ||||
