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| H | CF América | - | Deportivo Guadalajara | 1:0 (0:0) | ||
| R | Deportivo Guadalajara | - | CF América | 2:2 (0:0) | ||
| H: 27.11.2020 19:00 | R: 01.12.2020 00:00 | Sieger: CF América | ||||
| H | Pumas UNAM | - | CF Monterrey | 1:1 (0:1) | ||
| R | CF Monterrey | - | Pumas UNAM | 4:0 (1:0) | ||
| H: 27.11.2020 22:45 | R: 01.12.2020 04:00 | Sieger: CF Monterrey | ||||
| H | Gallos Blancos | - | Atlas Guadalajara | 1:2 (0:1) | ||
| R | Atlas Guadalajara | - | Gallos Blancos | 2:3 (2:1) | ||
| H: 28.11.2020 02:00 | R: 30.11.2020 17:00 | Sieger: Gallos Blancos | ||||
| H | CF Pachuca | - | UANL Tigres | 1:2 (0:1) | ||
| R | UANL Tigres | - | CF Pachuca | 4:1 (3:0) | ||
| H: 28.11.2020 04:00 | R: 01.12.2020 02:00 | Sieger: UANL Tigres | ||||
