 |
 |
|
| 20.11.2021 | 00:00 | Deportivo Toluca | - | Deportivo Guadalajara | 0:4 (0:1) | |
| 17:00 | CF América | - | Club León | 4:1 (3:1) | ||
| 19:00 | Pumas UNAM | - | Mazatlán FC | 4:0 (4:0) | ||
| 21.11.2021 | 00:00 | CF Monterrey | - | Cruz Azul | 5:0 (4:0) | |
| 00:00 | FC Juárez | - | Club Tijuana | 2:4 (1:2) | ||
| 02:00 | CF Pachuca | - | Gallos Blancos | 2:0 (2:0) | ||
| 19:00 | Puebla FC | - | Atlas Guadalajara | 0:4 (0:2) | ||
| 22.11.2021 | 00:00 | Atlético San Luis | - | Club Necaxa | 1:1 (1:0) | |
| 04:00 | Santos Laguna | - | UANL Tigres | 0:2 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UANL Tigres | 17 | 15 | 2 | 0 | 52:7 | 45 | 47 |
| 2 |
|
CF Monterrey | 17 | 14 | 2 | 1 | 45:10 | 35 | 44 |
| 3 |
|
Atlas Guadalajara | 17 | 11 | 3 | 3 | 30:16 | 14 | 36 |
| 4 |
|
Deportivo Guadalajara | 17 | 10 | 3 | 4 | 35:17 | 18 | 33 |
| 5 |
|
CF América | 17 | 9 | 4 | 4 | 33:19 | 14 | 31 |
| 6 |
|
Santos Laguna | 17 | 9 | 3 | 5 | 37:26 | 11 | 30 |
| 7 |
|
Club Tijuana | 17 | 9 | 3 | 5 | 30:19 | 11 | 30 |
| 8 |
|
Cruz Azul | 17 | 7 | 3 | 7 | 15:28 | -13 | 24 |
| 9 |
|
CF Pachuca | 17 | 6 | 5 | 6 | 28:24 | 4 | 23 |
| 10 |
|
Pumas UNAM | 17 | 5 | 6 | 6 | 19:16 | 3 | 21 |
| 11 |
|
Puebla FC | 17 | 5 | 3 | 9 | 18:30 | -12 | 18 |
| 12 |
|
Deportivo Toluca | 17 | 5 | 3 | 9 | 13:27 | -14 | 18 |
| 13 |
|
Club Necaxa | 17 | 5 | 3 | 9 | 16:34 | -18 | 18 |
| 14 |
|
Gallos Blancos | 17 | 4 | 4 | 9 | 19:23 | -4 | 16 |
| 15 |
|
Club León | 17 | 3 | 5 | 9 | 18:30 | -12 | 14 |
| 16 |
|
Atlético San Luis | 17 | 2 | 7 | 8 | 14:32 | -18 | 13 |
| 17 |
|
Mazatlán FC | 17 | 1 | 3 | 13 | 6:40 | -34 | 6 |
| 18 |
|
FC Juárez | 17 | 1 | 2 | 14 | 11:41 | -30 | 5 |
| Playoffs |
