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| H | CF Pachuca | - | CF América | 1:3 (0:2) | ||
| R | CF América | - | CF Pachuca | 0:1 (0:1) | ||
| H: 03.05.2012 03:30 | R: 06.05.2012 01:00 | Sieger: CF América | ||||
| H | Club Tijuana | - | CF Monterrey | 1:2 (0:1) | ||
| R | CF Monterrey | - | Club Tijuana | 2:2 (1:1) | ||
| H: 03.05.2012 05:30 | R: 06.05.2012 03:00 | Sieger: CF Monterrey | ||||
| H | Jaguares Chiapas | - | Santos Laguna | 3:4 (2:2) | ||
| R | Santos Laguna | - | Jaguares Chiapas | 2:1 (2:1) | ||
| H: 04.05.2012 02:00 | R: 07.05.2012 01:00 | Sieger: Santos Laguna | ||||
| H | UANL Tigres | - | Monarcas Morelia | 1:0 (1:0) | ||
| R | Monarcas Morelia | - | UANL Tigres | 1:4 (0:0) | ||
| H: 04.05.2012 04:00 | R: 07.05.2012 03:00 | Sieger: UANL Tigres | ||||
