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| H | Atlas Guadalajara | - | UANL Tigres | 3:0 (1:0) | ||
| R | UANL Tigres | - | Atlas Guadalajara | 4:2 (0:1) | ||
| H: 19.05.2022 04:00 | R: 22.05.2022 03:00 | Sieger: Atlas Guadalajara | ||||
| H | CF América | - | CF Pachuca | 1:1 (0:0) | ||
| R | CF Pachuca | - | CF América | 3:0 (2:0) | ||
| H: 20.05.2022 03:00 | R: 23.05.2022 03:06 | Sieger: CF Pachuca | ||||
