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| H | CF Monterrey | - | Pumas UNAM | 2:0 (1:0) | ||
| R | Pumas UNAM | - | CF Monterrey | 2:0 (0:0) | ||
| H: 08.05.2019 16:00 | R: 11.05.2019 19:00 | |||||
| H | Club Necaxa | - | Atlas Guadalajara | 1:2 (0:2) | ||
| R | Atlas Guadalajara | - | Club Necaxa | 6:1 (2:1) | ||
| H: 08.05.2019 16:00 | R: 11.05.2019 16:00 | Sieger: Atlas Guadalajara | ||||
| H | CF Pachuca | - | Monarcas Morelia | 1:1 (0:0) | ||
| R | Monarcas Morelia | - | CF Pachuca | 1:1 (1:0) | ||
| H: 08.05.2019 17:00 | R: 11.05.2019 17:00 | |||||
| H | CF América | - | Santos Laguna | 0:0 (0:0) | ||
| R | Santos Laguna | - | CF América | 2:1 (0:0) | ||
| H: 09.05.2019 16:00 | R: 12.05.2019 16:00 | Sieger: Santos Laguna | ||||
