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| H | CF Pachuca | - | Club Necaxa | 1:2 (1:1) | ||
| R | Club Necaxa | - | CF Pachuca | 3:6 (1:1) | ||
| H: 25.11.2021 16:30 | R: 28.11.2021 16:00 | Sieger: CF Pachuca | ||||
| H | Atlas Guadalajara | - | CF América | 3:0 (2:0) | ||
| R | CF América | - | Atlas Guadalajara | 3:2 (1:0) | ||
| H: 25.11.2021 18:30 | R: 28.11.2021 18:00 | Sieger: Atlas Guadalajara | ||||
