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| H | CF América | - | Atlas Guadalajara | 1:2 (0:1) | ||
| R | Atlas Guadalajara | - | CF América | 2:2 (2:1) | ||
| H: 12.10.2022 16:00 | R: 15.10.2022 16:00 | Sieger: Atlas Guadalajara | ||||
| H | Pumas UNAM | - | CF Pachuca | 1:2 (1:0) | ||
| R | CF Pachuca | - | Pumas UNAM | 0:3 (0:2) | ||
| H: 13.10.2022 17:00 | R: 16.10.2022 19:00 | Sieger: Pumas UNAM | ||||
