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| 12.02.2022 | 14:00 | FK Bregalnica Štip | - | FK Renova | 1:2 (0:1) | |
| 13.02.2022 | 14:00 | FK Pelister | - | FK Rabotnički | 0:2 (0:0) | |
| 14:00 | KF Shkupi | - | Akademija Pandev | 2:1 (1:1) | ||
| 14:00 | FK Skopje | - | FK Borec | 1:1 (1:1) | ||
| 14:00 | KF Shkëndija 79 | - | FC Struga | 3:1 (2:0) | ||
| 14:00 | Makedonija GP | - | GFK Tikvesh | 1:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 19 | 14 | 3 | 2 | 45:12 | 33 | 45 |
| 2 |
|
KF Shkëndija 79 | 19 | 10 | 7 | 2 | 31:15 | 16 | 37 |
| 3 |
|
Akademija Pandev | 19 | 10 | 5 | 4 | 29:20 | 9 | 35 |
| 4 |
|
FK Renova | 19 | 8 | 6 | 5 | 27:17 | 10 | 30 |
| 5 |
|
Makedonija GP | 19 | 9 | 3 | 7 | 28:31 | -3 | 30 |
| 6 |
|
FK Bregalnica Štip | 19 | 8 | 5 | 6 | 28:27 | 1 | 29 |
| 7 |
|
FC Struga | 19 | 6 | 8 | 5 | 15:17 | -2 | 26 |
| 8 |
|
FK Rabotnički | 19 | 7 | 4 | 8 | 15:19 | -4 | 25 |
| 9 |
|
FK Skopje | 19 | 5 | 6 | 8 | 14:23 | -9 | 21 |
| 10 |
|
GFK Tikvesh | 19 | 3 | 6 | 10 | 16:24 | -8 | 15 |
| 11 |
|
FK Borec | 19 | 3 | 4 | 12 | 17:35 | -18 | 13 |
| 12 |
|
FK Pelister | 19 | 0 | 5 | 14 | 6:31 | -25 | 5 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Relegation | |
| Abstieg |
