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| 10.04.2022 | 14:00 | FK Rabotnički | - | GFK Tikvesh | 1:0 (1:0) | |
| 16:00 | FC Struga | - | FK Skopje | 1:0 (0:0) | ||
| 16:00 | KF Shkupi | - | FK Borec | 3:1 (1:1) | ||
| 16:00 | Akademija Pandev | - | FK Pelister | 2:0 (0:0) | ||
| 16:00 | KF Shkëndija 79 | - | FK Renova | 1:1 (1:0) | ||
| 16:00 | Makedonija GP | - | FK Bregalnica Štip | 1:1 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 27 | 20 | 5 | 2 | 58:16 | 42 | 65 |
| 2 |
|
KF Shkëndija 79 | 27 | 14 | 10 | 3 | 42:19 | 23 | 52 |
| 3 |
|
Akademija Pandev | 27 | 15 | 7 | 5 | 46:24 | 22 | 52 |
| 4 |
|
Makedonija GP | 27 | 15 | 5 | 7 | 40:35 | 5 | 50 |
| 5 |
|
FK Renova | 27 | 9 | 11 | 7 | 33:24 | 9 | 38 |
| 6 |
|
FK Bregalnica Štip | 27 | 10 | 8 | 9 | 38:39 | -1 | 38 |
| 7 |
|
FK Rabotnički | 27 | 11 | 4 | 12 | 24:28 | -4 | 37 |
| 8 |
|
FC Struga | 27 | 9 | 9 | 9 | 23:28 | -5 | 36 |
| 9 |
|
FK Skopje | 27 | 6 | 8 | 13 | 17:37 | -20 | 26 |
| 10 |
|
GFK Tikvesh | 27 | 6 | 6 | 15 | 26:33 | -7 | 24 |
| 11 |
|
FK Borec | 27 | 3 | 6 | 18 | 19:52 | -33 | 15 |
| 12 |
|
FK Pelister | 27 | 1 | 7 | 19 | 10:41 | -31 | 10 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Relegation | |
| Abstieg |
