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| 02.04.2021 | 18:00 | Go Ahead Eagles | - | Roda JC Kerkrade | 0:0 (0:0) | |
| 20:00 | Almere City FC | - | NEC Nijmegen | 2:0 (1:0) | ||
| 20:00 | De Graafschap | - | FC Dordrecht | 0:3 (0:1) | ||
| 20:00 | FC Den Bosch | - | TOP Oss | 1:0 (0:0) | ||
| 20:00 | SBV Excelsior | - | Jong PSV | 0:0 (0:0) | ||
| 20:00 | FC Volendam | - | SC Cambuur | 0:3 (0:2) | ||
| 20:00 | Helmond Sport | - | AZ Alkmaar (J) | 2:0 (1:0) | ||
| 20:00 | Jong Ajax | - | NAC Breda | 1:1 (0:0) | ||
| 20:00 | MVV | - | FC Eindhoven | 2:0 (0:0) | ||
| 20:00 | Telstar | - | FC Utrecht (J) | 2:3 (1:2) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Cambuur | 31 | 23 | 4 | 4 | 84:25 | 59 | 73 |
| 2 |
|
Almere City FC | 31 | 20 | 5 | 6 | 67:40 | 27 | 65 |
| 3 |
|
De Graafschap | 31 | 20 | 4 | 7 | 59:43 | 16 | 64 |
| 4 |
|
NAC Breda | 31 | 19 | 6 | 6 | 62:31 | 31 | 63 |
| 5 |
|
Go Ahead Eagles | 31 | 17 | 8 | 6 | 49:22 | 27 | 59 |
| 6 |
|
NEC Nijmegen | 31 | 17 | 5 | 9 | 59:35 | 24 | 56 |
| 7 |
|
FC Volendam | 31 | 14 | 8 | 9 | 64:44 | 20 | 50 |
| 8 |
|
Roda JC Kerkrade | 31 | 13 | 10 | 8 | 58:45 | 13 | 49 |
| 9 |
|
Helmond Sport | 31 | 10 | 9 | 12 | 45:52 | -7 | 39 |
| 10 |
|
SBV Excelsior | 31 | 11 | 5 | 15 | 54:53 | 1 | 38 |
| 11 |
|
MVV | 31 | 11 | 5 | 15 | 39:58 | -19 | 38 |
| 12 |
|
Telstar | 31 | 10 | 7 | 14 | 50:48 | 2 | 37 |
| 13 |
|
Jong Ajax | 31 | 9 | 8 | 14 | 51:62 | -11 | 35 |
| 14 |
|
TOP Oss | 31 | 10 | 5 | 16 | 32:50 | -18 | 35 |
| 15 |
|
Jong PSV | 31 | 8 | 7 | 16 | 46:58 | -12 | 31 |
| 16 |
|
FC Utrecht (J) | 31 | 10 | 1 | 20 | 43:64 | -21 | 31 |
| 17 |
|
FC Eindhoven | 31 | 7 | 9 | 15 | 38:54 | -16 | 30 |
| 18 |
|
FC Dordrecht | 31 | 8 | 3 | 20 | 32:75 | -43 | 27 |
| 19 |
|
AZ Alkmaar (J) | 31 | 7 | 5 | 19 | 42:81 | -39 | 26 |
| 20 |
|
FC Den Bosch | 31 | 5 | 8 | 18 | 37:71 | -34 | 23 |
| Aufstieg | |
| Playoffs |
