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| 01.10.2021 | 20:00 | FC Den Bosch | - | Telstar | 0:1 (0:0) | |
| 20:00 | TOP Oss | - | De Graafschap | 0:3 (0:0) | ||
| 20:00 | FC Volendam | - | Almere City FC | 3:2 (1:1) | ||
| 20:00 | Helmond Sport | - | Jong Ajax | 3:1 (1:1) | ||
| 20:00 | AZ Alkmaar (J) | - | FC Dordrecht | 2:1 (1:1) | ||
| 20:00 | FC Utrecht (J) | - | FC Emmen | 0:1 (0:1) | ||
| 20:00 | Jong PSV | - | VVV-Venlo | 2:1 (2:0) | ||
| 20:00 | MVV | - | ADO Den Haag | 2:6 (0:3) | ||
| 20:00 | NAC Breda | - | SBV Excelsior | 4:1 (1:0) | ||
| 20:00 | Roda JC Kerkrade | - | FC Eindhoven | 2:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Volendam | 9 | 5 | 3 | 1 | 22:13 | 9 | 18 |
| 2 |
|
AZ Alkmaar (J) | 9 | 6 | 0 | 3 | 11:8 | 3 | 18 |
| 3 |
|
FC Emmen | 9 | 5 | 1 | 3 | 15:8 | 7 | 16 |
| 4 |
|
SBV Excelsior | 9 | 5 | 1 | 3 | 18:12 | 6 | 16 |
| 5 |
|
De Graafschap | 9 | 5 | 1 | 3 | 16:12 | 4 | 16 |
| 6 |
|
FC Utrecht (J) | 9 | 4 | 3 | 2 | 14:8 | 6 | 15 |
| 7 |
|
Roda JC Kerkrade | 9 | 4 | 2 | 3 | 17:13 | 4 | 14 |
| 8 |
|
ADO Den Haag | 9 | 6 | 1 | 2 | 22:13 | 9 | 13 |
| 9 |
|
VVV-Venlo | 9 | 4 | 1 | 4 | 11:11 | 0 | 13 |
| 10 |
|
FC Eindhoven | 9 | 4 | 1 | 4 | 13:14 | -1 | 13 |
| 11 |
|
Jong Ajax | 9 | 4 | 0 | 5 | 20:20 | 0 | 12 |
| 12 |
|
Telstar | 9 | 3 | 3 | 3 | 10:14 | -4 | 12 |
| 13 |
|
MVV | 9 | 4 | 0 | 5 | 13:26 | -13 | 12 |
| 14 |
|
Jong PSV | 9 | 3 | 1 | 5 | 10:13 | -3 | 10 |
| 15 |
|
TOP Oss | 9 | 3 | 1 | 5 | 11:16 | -5 | 10 |
| 16 |
|
Almere City FC | 9 | 2 | 3 | 4 | 17:18 | -1 | 9 |
| 17 |
|
NAC Breda | 9 | 2 | 3 | 4 | 15:17 | -2 | 9 |
| 18 |
|
FC Den Bosch | 9 | 3 | 0 | 6 | 8:15 | -7 | 9 |
| 19 |
|
Helmond Sport | 9 | 3 | 0 | 6 | 10:15 | -5 | 6 |
| 20 |
|
FC Dordrecht | 9 | 1 | 3 | 5 | 9:16 | -7 | 6 |
| Aufstieg | |
| Playoffs | |
| Playoffs |
|
# ADO Den Haag: -6 P. # Helmond Sport: -3 P. |
