 |
|
 |
| 18.01.2022 | 18:45 | RKC Waalwijk | - | ADO Den Haag | 4:2 (1:2, 2:2, 4:2) n.V. | |
| 20:00 | Vitesse | - | DVS'33 | 2:0 (1:0) | ||
| 21:00 | sc Heerenveen | - | Go Ahead Eagles | 0:1 (0:1) | ||
| 19.01.2022 | 18:45 | FC Groningen | - | NEC Nijmegen | 1:2 (1:1) | |
| 20:00 | NAC Breda | - | PEC Zwolle | 2:1 (1:1) | ||
| 21:00 | FC Twente | - | AZ Alkmaar | 1:2 (0:0) | ||
| 20.01.2022 | 18:45 | PSV Eindhoven | - | SC Telstar | 2:1 (1:1) | |
| 21:00 | AFC Ajax | - | Excelsior Maassluis | 9:0 (5:0) |
