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| 04.03.2022 | 20:45 | Cliftonville FC | - | Coleraine FC | 2:1 | |
| 05.03.2022 | 16:00 | Ballymena United | - | Larne FC | 4:3 i.E. | |
| 16:00 | Crusaders FC | - | Dungannon Swifts | 4:2 | ||
| 16:00 | Glentoran FC | - | Newry City FC | 0:1 Wert. |
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# Glentoran were expelled from the cup for fielding an ineligible player in this match, with Newry City being reinstated to the semi-finals. |
