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| 13.10.2021 | 20:45 | Carrick Rangers | - | Coleraine FC | 0:2 | |
| 20:45 | Crusaders FC | - | Ballymena United | 2:3 n.V. | ||
| 20:45 | Glenavon FC | - | Glentoran FC | 4:5 i.E. | ||
| 20:45 | Warrenpoint Town | - | Loughgall FC | 1:0 | ||
| 26.10.2021 | 20:45 | Portadown FC | - | Ballinamallard United FC | 1:0 | |
| 21:00 | Ards FC | - | Cliftonville FC | 1:4 | ||
| 02.11.2021 | 20:45 | Limavady United | - | Dungannon Swifts | 3:2 | |
| 20:45 | Linfield FC | - | PSNI FC | 11:0 |
