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| 16.10.2021 | 14:00 | FV Ravensburg | - | 1. FC Rielasingen-Arlen | 1:1 (1:0) | |
| 14:00 | SGV Freiberg | - | Freiburger FC | 2:1 (1:1) | ||
| 14:00 | Stuttgarter Kickers | - | 1. FC Bruchsal | 3:0 (1:0) | ||
| 14:00 | TSG Backnang | - | Neckarsulmer Sport-Union | 3:0 (1:0) | ||
| 14:00 | FC-Astoria Walldorf II | - | TSV Ilshofen | 3:0 (1:0) | ||
| 14:00 | Sportfreunde Dorfmerkingen | - | FV Lörrach-Brombach | 2:2 (2:1) | ||
| 15:30 | FC 08 Villingen | - | SV Linx | 2:0 (1:0) | ||
| 15:30 | FC Nöttingen | - | Göppinger SV | 4:1 (4:0) | ||
| 15:30 | SSV Reutlingen | - | 1. CfR Pforzheim | 1:0 (1:0) | ||
| 17.10.2021 | 15:00 | SV Oberachern | - | FSV 08 Bietigheim-Bissingen | 3:1 (2:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Stuttgarter Kickers | 13 | 9 | 2 | 2 | 25:6 | 19 | 29 |
| 2 |
|
SGV Freiberg | 13 | 8 | 4 | 1 | 38:11 | 27 | 28 |
| 3 |
|
TSG Backnang | 13 | 8 | 1 | 4 | 28:17 | 11 | 25 |
| 4 |
|
FSV 08 Bietigheim-Bissingen | 13 | 7 | 3 | 3 | 32:14 | 18 | 24 |
| 5 |
|
FC 08 Villingen | 13 | 7 | 2 | 4 | 22:16 | 6 | 23 |
| 6 |
|
FC-Astoria Walldorf II | 13 | 7 | 2 | 4 | 22:19 | 3 | 23 |
| 7 |
|
Göppinger SV | 13 | 6 | 4 | 3 | 20:17 | 3 | 22 |
| 8 |
|
1. FC Rielasingen-Arlen | 13 | 6 | 3 | 4 | 15:14 | 1 | 21 |
| 9 |
|
FV Ravensburg | 13 | 5 | 4 | 4 | 29:21 | 8 | 19 |
| 10 |
|
1. CfR Pforzheim | 13 | 6 | 1 | 6 | 18:18 | 0 | 19 |
| 11 |
|
Neckarsulmer Sport-Union | 13 | 5 | 3 | 5 | 20:21 | -1 | 18 |
| 12 |
|
FC Nöttingen | 13 | 5 | 2 | 6 | 27:22 | 5 | 17 |
| 13 |
|
SSV Reutlingen | 13 | 4 | 4 | 5 | 17:19 | -2 | 16 |
| 14 |
|
SV Oberachern | 13 | 5 | 1 | 7 | 21:26 | -5 | 16 |
| 15 |
|
SV Linx | 13 | 4 | 3 | 6 | 12:30 | -18 | 15 |
| 16 |
|
Freiburger FC | 13 | 3 | 4 | 6 | 15:20 | -5 | 13 |
| 17 |
|
Sportfreunde Dorfmerkingen | 13 | 3 | 4 | 6 | 15:29 | -14 | 13 |
| 18 |
|
TSV Ilshofen | 13 | 2 | 2 | 9 | 13:30 | -17 | 8 |
| 19 |
|
1. FC Bruchsal | 13 | 2 | 2 | 9 | 12:31 | -19 | 8 |
| 20 |
|
FV Lörrach-Brombach | 13 | 1 | 3 | 9 | 9:29 | -20 | 6 |
| Aufstieg | |
| Relegation | |
| Abstieg |
