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| 19.03.2022 | 14:00 | Göppinger SV | - | 1. CfR Pforzheim | 1:0 (0:0) | |
| 14:00 | SGV Freiberg | - | TSG Backnang | 1:1 (0:0) | ||
| 14:00 | Stuttgarter Kickers | - | FC 08 Villingen | 1:1 (0:1) | ||
| 14:00 | Sportfreunde Dorfmerkingen | - | SSV Reutlingen | 3:0 (1:0) | ||
| 15:00 | FSV 08 Bietigheim-Bissingen | - | Freiburger FC | 1:0 (1:0) | ||
| 15:30 | 1. FC Bruchsal | - | TSV Ilshofen | 4:1 (0:0) | ||
| 15:30 | FC-Astoria Walldorf II | - | FV Ravensburg | 2:4 (2:2) | ||
| 15:30 | FC Nöttingen | - | 1. FC Rielasingen-Arlen | 3:2 (2:0) | ||
| 15:30 | SV Oberachern | - | SV Linx | 1:1 (0:0) | ||
| 06.04.2022 | 19:00 | FV Lörrach-Brombach | - | Neckarsulmer Sport-Union | 0:2 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SGV Freiberg | 25 | 18 | 6 | 1 | 78:18 | 60 | 60 |
| 2 |
|
Stuttgarter Kickers | 25 | 18 | 3 | 4 | 54:16 | 38 | 57 |
| 3 |
|
Göppinger SV | 25 | 14 | 5 | 6 | 43:33 | 10 | 47 |
| 4 |
|
TSG Backnang | 25 | 13 | 3 | 9 | 56:36 | 20 | 42 |
| 5 |
|
FC 08 Villingen | 25 | 12 | 5 | 8 | 46:30 | 16 | 41 |
| 6 |
|
1. FC Rielasingen-Arlen | 25 | 12 | 5 | 8 | 39:32 | 7 | 41 |
| 7 |
|
FC Nöttingen | 25 | 12 | 4 | 9 | 50:46 | 4 | 40 |
| 8 |
|
1. CfR Pforzheim | 25 | 12 | 3 | 10 | 41:34 | 7 | 39 |
| 9 |
|
FSV 08 Bietigheim-Bissingen | 25 | 10 | 7 | 8 | 47:35 | 12 | 37 |
| 10 |
|
FV Ravensburg | 25 | 9 | 9 | 7 | 51:42 | 9 | 36 |
| 11 |
|
Neckarsulmer Sport-Union | 25 | 10 | 6 | 9 | 35:37 | -2 | 36 |
| 12 |
|
SV Oberachern | 25 | 10 | 3 | 12 | 41:46 | -5 | 33 |
| 13 |
|
SSV Reutlingen | 25 | 8 | 6 | 11 | 33:38 | -5 | 30 |
| 14 |
|
SV Linx | 25 | 7 | 8 | 10 | 29:51 | -22 | 29 |
| 15 |
|
FC-Astoria Walldorf II | 25 | 8 | 4 | 13 | 36:53 | -17 | 28 |
| 16 |
|
Sportfreunde Dorfmerkingen | 25 | 7 | 6 | 12 | 30:51 | -21 | 27 |
| 17 |
|
Freiburger FC | 25 | 7 | 5 | 13 | 37:40 | -3 | 26 |
| 18 |
|
1. FC Bruchsal | 25 | 6 | 5 | 14 | 31:59 | -28 | 23 |
| 19 |
|
TSV Ilshofen | 25 | 4 | 6 | 15 | 28:59 | -31 | 18 |
| 20 |
|
FV Lörrach-Brombach | 25 | 1 | 5 | 19 | 18:67 | -49 | 8 |
| Aufstieg | |
| Relegation | |
| Abstieg |
