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| 03.11.2021 | 21:00 | Libertad | - | Sportivo Luqueño | 2:0 (0:0) | |
| 23:30 | Atlético Tembetary | - | Tacuary | 4:2 i.E. | ||
| 04.11.2021 | 21:45 | Club Olimpia | - | Guaireña FC | 2:0 | |
| 10.11.2021 | 23:30 | Sol de América | - | Deportivo Santaní | 1:0 |
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|
|
|
| 03.11.2021 | 21:00 | Libertad | - | Sportivo Luqueño | 2:0 (0:0) | |
| 23:30 | Atlético Tembetary | - | Tacuary | 4:2 i.E. | ||
| 04.11.2021 | 21:45 | Club Olimpia | - | Guaireña FC | 2:0 | |
| 10.11.2021 | 23:30 | Sol de América | - | Deportivo Santaní | 1:0 |
