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| 03.11.2021 | 12:00 | Vitória Guimarães | - | Leixões SC | 2:3 (1:1) | |
| 05.11.2021 | 12:00 | Sporting Braga | - | Rio Ave FC | 5:1 (2:1) | |
| 18:00 | SC Farense | - | Portimonense SC | 0:2 (0:0) | ||
| 06.11.2021 | 12:00 | FC Famalicão | - | Académica de Coimbra | 2:1 (1:0) | |
| 07.11.2021 | 12:00 | CS Marítimo | - | SL Benfica | 0:2 (0:0) | |
| 14:00 | Belenenses SAD | - | Sporting CP | 3:0 (2:0) |
| 1 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sporting Braga | 8 | 6 | 1 | 1 | 16:4 | 12 | 19 |
| 2 |
|
Rio Ave FC | 8 | 5 | 2 | 1 | 9:8 | 1 | 17 |
| 3 |
|
Leixões SC | 7 | 4 | 1 | 2 | 8:5 | 3 | 13 |
| 4 |
|
Vitória Guimarães | 8 | 3 | 2 | 3 | 14:11 | 3 | 11 |
| 5 |
|
FC Famalicão | 8 | 3 | 1 | 4 | 9:11 | -2 | 10 |
| 6 |
|
FC Vizela | 7 | 1 | 2 | 4 | 6:13 | -7 | 5 |
| 7 |
|
Académica de Coimbra | 8 | 0 | 1 | 7 | 5:15 | -10 | 1 |
| 2 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
GD Estoril | 7 | 6 | 1 | 0 | 14:4 | 10 | 19 |
| 2 |
|
SL Benfica | 7 | 4 | 2 | 1 | 10:5 | 5 | 14 |
| 3 |
|
Portimonense SC | 8 | 4 | 2 | 2 | 11:11 | 0 | 14 |
| 4 |
|
Sporting CP | 8 | 3 | 2 | 3 | 12:13 | -1 | 11 |
| 5 |
|
CS Marítimo | 8 | 3 | 1 | 4 | 12:11 | 1 | 10 |
| 6 |
|
Belenenses SAD | 8 | 2 | 1 | 5 | 12:18 | -6 | 7 |
| 7 |
|
SC Farense | 8 | 0 | 1 | 7 | 5:14 | -9 | 1 |
| Playoffs | |
| Relegation | |
| Playoffs | |
| Relegation |
