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| 30.01.2021 | 14:00 | Bahlinger SC | - | SG Sonnenhof Großaspach | 1:0 (0:0) | |
| 14:00 | Eintracht Stadtallendorf | - | VfB Stuttgart II | 1:5 (1:1) | ||
| 14:00 | FC 08 Homburg | - | SSV Ulm 1846 | 4:4 (1:0) | ||
| 14:00 | FC-Astoria Walldorf | - | TSG Balingen | 3:1 (2:1) | ||
| 14:00 | 1. FSV Mainz 05 II | - | Kickers Offenbach | 1:1 (1:1) | ||
| 14:00 | Hessen Kassel | - | FC Gießen | 1:1 (1:1) | ||
| 14:00 | Rot-Weiß Koblenz | - | SC Freiburg II | 1:3 (0:0) | ||
| 14:00 | SV 07 Elversberg | - | Bayern Alzenau | 3:3 (2:1) | ||
| 14:00 | TSV Schott Mainz | - | FK Pirmasens | 1:1 (1:1) | ||
| 14:00 | VfR Aalen | - | 1899 Hoffenheim II | 3:1 (1:0) | ||
| 16.03.2021 | 19:00 | FSV Frankfurt | - | TSV Steinbach Haiger | 1:1 (0:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg II | 21 | 13 | 5 | 3 | 52:23 | 29 | 44 |
| 2 |
|
FSV Frankfurt | 21 | 12 | 5 | 4 | 32:20 | 12 | 41 |
| 3 |
|
TSV Steinbach Haiger | 21 | 12 | 4 | 5 | 42:23 | 19 | 40 |
| 4 |
|
SV 07 Elversberg | 21 | 9 | 9 | 3 | 45:26 | 19 | 36 |
| 5 |
|
SSV Ulm 1846 | 21 | 10 | 6 | 5 | 40:21 | 19 | 36 |
| 6 |
|
Kickers Offenbach | 21 | 9 | 9 | 3 | 32:13 | 19 | 36 |
| 7 |
|
VfB Stuttgart II | 21 | 9 | 5 | 7 | 42:24 | 18 | 32 |
| 8 |
|
TSG Balingen | 21 | 9 | 5 | 7 | 32:25 | 7 | 32 |
| 9 |
|
FC 08 Homburg | 21 | 8 | 6 | 7 | 39:31 | 8 | 30 |
| 10 |
|
Bahlinger SC | 21 | 8 | 6 | 7 | 32:39 | -7 | 30 |
| 11 |
|
1. FSV Mainz 05 II | 21 | 7 | 6 | 8 | 25:31 | -6 | 27 |
| 12 |
|
VfR Aalen | 21 | 7 | 6 | 8 | 24:30 | -6 | 27 |
| 13 |
|
FC Gießen | 21 | 7 | 5 | 9 | 23:27 | -4 | 26 |
| 14 |
|
Hessen Kassel | 21 | 6 | 8 | 7 | 31:36 | -5 | 26 |
| 15 |
|
FK Pirmasens | 21 | 6 | 8 | 7 | 19:30 | -11 | 26 |
| 16 |
|
Rot-Weiß Koblenz | 21 | 7 | 4 | 10 | 22:31 | -9 | 25 |
| 17 |
|
SG Sonnenhof Großaspach | 21 | 6 | 5 | 10 | 21:33 | -12 | 23 |
| 18 |
|
FC-Astoria Walldorf | 21 | 6 | 4 | 11 | 26:36 | -10 | 22 |
| 19 |
|
1899 Hoffenheim II | 21 | 6 | 4 | 11 | 28:39 | -11 | 22 |
| 20 |
|
Bayern Alzenau | 21 | 5 | 6 | 10 | 25:40 | -15 | 21 |
| 21 |
|
TSV Schott Mainz | 21 | 5 | 4 | 12 | 30:55 | -25 | 19 |
| 22 |
|
Eintracht Stadtallendorf | 21 | 1 | 6 | 14 | 18:47 | -29 | 9 |
| Aufstieg | |
| Abstieg |
