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| 10.04.2021 | 14:00 | 1. FC Köln II | - | VfB Homberg | 5:2 (1:2) | |
| 14:00 | Alemannia Aachen | - | Wuppertaler SV | 0:2 (0:1) | ||
| 14:00 | Bonner SC | - | FC Schalke 04 II | 0:3 (0:2) | ||
| 14:00 | Bor. Mönchengladbach II | - | Borussia Dortmund II | 1:4 (0:2) | ||
| 14:00 | FC Wegberg-Beeck | - | Fortuna Düsseldorf II | 2:0 (1:0) | ||
| 14:00 | Rot Weiss Ahlen | - | Preußen Münster | 2:3 (1:1) | ||
| 14:00 | Rot-Weiss Essen | - | SV Bergisch Gladbach 09 | 4:0 (2:0) | ||
| 14:00 | SC Wiedenbrück | - | SV Rödinghausen | 0:2 (0:1) | ||
| 14:00 | Sportfreunde Lotte | - | SV 19 Straelen | 0:0 (0:0) | ||
| 14:00 | Fortuna Köln | - | SV Lippstadt 08 | 1:0 (1:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Borussia Dortmund II | 33 | 23 | 9 | 1 | 80:23 | 57 | 78 |
| 2 |
|
Rot-Weiss Essen | 33 | 21 | 9 | 3 | 72:21 | 51 | 72 |
| 3 |
|
Preußen Münster | 33 | 19 | 8 | 6 | 52:29 | 23 | 65 |
| 4 |
|
Fortuna Köln | 33 | 15 | 11 | 7 | 54:37 | 17 | 56 |
| 5 |
|
Fortuna Düsseldorf II | 33 | 15 | 9 | 9 | 59:35 | 24 | 54 |
| 6 |
|
1. FC Köln II | 33 | 15 | 8 | 10 | 60:46 | 14 | 53 |
| 7 |
|
SV Rödinghausen | 34 | 14 | 11 | 9 | 46:34 | 12 | 53 |
| 8 |
|
Rot-Weiß Oberhausen | 33 | 13 | 11 | 9 | 52:41 | 11 | 50 |
| 9 |
|
FC Schalke 04 II | 34 | 12 | 11 | 11 | 44:44 | 0 | 47 |
| 10 |
|
Wuppertaler SV | 34 | 13 | 6 | 15 | 44:52 | -8 | 45 |
| 11 |
|
SC Wiedenbrück | 33 | 10 | 14 | 9 | 41:42 | -1 | 44 |
| 12 |
|
SV 19 Straelen | 34 | 11 | 11 | 12 | 39:49 | -10 | 44 |
| 13 |
|
Bor. Mönchengladbach II | 33 | 12 | 6 | 15 | 41:49 | -8 | 42 |
| 14 |
|
Alemannia Aachen | 34 | 10 | 11 | 13 | 31:38 | -7 | 41 |
| 15 |
|
FC Wegberg-Beeck | 33 | 8 | 11 | 14 | 30:48 | -18 | 35 |
| 16 |
|
Sportfreunde Lotte | 33 | 7 | 12 | 14 | 33:59 | -26 | 33 |
| 17 |
|
VfB Homberg | 34 | 8 | 7 | 19 | 33:60 | -27 | 31 |
| 18 |
|
SV Lippstadt 08 | 33 | 5 | 13 | 15 | 30:54 | -24 | 28 |
| 19 |
|
SV Bergisch Gladbach 09 | 34 | 6 | 8 | 20 | 28:60 | -32 | 26 |
| 20 |
|
Rot Weiss Ahlen | 33 | 4 | 13 | 16 | 38:58 | -20 | 25 |
| 21 |
|
Bonner SC | 33 | 6 | 7 | 20 | 31:59 | -28 | 25 |
| Aufstieg | |
| Abstieg |
