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| 08.02.2022 | 14:00 | Sepsi OSK | - | Gaz Metan Mediaş | 2:0 (0:0) | |
| 16:30 | CFR Cluj | - | UTA Arad | 0:0 (0:0) | ||
| 18:55 | FC Voluntari | - | Rapid Bucureşti | 0:0 (0:0) | ||
| 09.02.2022 | 14:00 | Chindia Târgoviște | - | Argeș Pitești | 1:1 (1:0) | |
| 16:30 | CS Mioveni | - | Farul Constanța | 1:1 (1:1) | ||
| 18:55 | Academica Clinceni | - | FCSB | 0:3 (0:2) | ||
| 10.02.2022 | 16:00 | FC Universitatea Craiova | - | FC Botoşani | 3:2 (2:2) | |
| 18:55 | Dinamo Bucureşti | - | CS Universitatea Craiova | 1:6 (0:2) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CFR Cluj | 25 | 19 | 4 | 2 | 37:13 | 24 | 61 |
| 2 |
|
FCSB | 25 | 16 | 7 | 2 | 49:22 | 27 | 55 |
| 3 |
|
FC Voluntari | 25 | 12 | 7 | 6 | 28:21 | 7 | 43 |
| 4 |
|
FC Botoşani | 25 | 10 | 11 | 4 | 29:23 | 6 | 41 |
| 5 |
|
CS Universitatea Craiova | 25 | 11 | 6 | 8 | 45:28 | 17 | 39 |
| 6 |
|
Farul Constanța | 25 | 11 | 6 | 8 | 35:19 | 16 | 39 |
| 7 |
|
Rapid Bucureşti | 25 | 8 | 11 | 6 | 28:24 | 4 | 35 |
| 8 |
|
Argeș Pitești | 25 | 10 | 5 | 10 | 23:21 | 2 | 35 |
| 9 |
|
Sepsi OSK | 25 | 7 | 11 | 7 | 26:21 | 5 | 32 |
| 10 |
|
UTA Arad | 25 | 7 | 11 | 7 | 19:17 | 2 | 32 |
| 11 |
|
Chindia Târgoviște | 25 | 6 | 10 | 9 | 15:18 | -3 | 28 |
| 12 |
|
CS Mioveni | 25 | 6 | 9 | 10 | 17:29 | -12 | 27 |
| 13 |
|
FC Universitatea Craiova | 25 | 6 | 8 | 11 | 23:28 | -5 | 26 |
| 14 |
|
Dinamo Bucureşti | 25 | 3 | 3 | 19 | 17:58 | -41 | 12 |
| 15 |
|
Academica Clinceni | 25 | 2 | 5 | 18 | 18:56 | -38 | 11 |
| 16 |
|
Gaz Metan Mediaş | 25 | 6 | 6 | 13 | 20:31 | -11 | 10 |
| Playoffs | |
| Relegation |
|
# Gaz Metan Mediaş wurden wegen finanzieller Unregelmäßigkeiten 14 Punkte abgezogen. |
