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| 21.05.2022 | 13:00 | Rubin Kazan | - | FK Krasnodar | 1:2 (1:0) | |
| 13:00 | Kuban Krasnodar | - | Lokomotiv Moskva | 1:0 (0:0) | ||
| 13:00 | CSKA Moskva | - | FK Strogino Moskva | 3:6 (0:4) | ||
| 13:00 | Dinamo Moskva | - | Chertanovo Football Academy | 0:2 (0:0) | ||
| 13:00 | Spartak Moskva | - | FK Rostov | 9:0 (3:0) | ||
| 13:00 | FK Saturn | - | SShOR Zenit | 2:2 (0:1) | ||
| 13:00 | Zenit St. Petersburg | - | FShM Moskva | 2:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FK Krasnodar | 26 | 18 | 5 | 3 | 64:23 | 41 | 59 |
| 2 |
|
Spartak Moskva | 26 | 18 | 4 | 4 | 72:21 | 51 | 58 |
| 3 |
|
Zenit St. Petersburg | 26 | 16 | 5 | 5 | 69:35 | 34 | 53 |
| 4 |
|
Chertanovo Football Academy | 26 | 16 | 3 | 7 | 61:36 | 25 | 51 |
| 5 |
|
FK Rostov | 26 | 14 | 6 | 6 | 44:33 | 11 | 48 |
| 6 |
|
FK Strogino Moskva | 26 | 14 | 3 | 9 | 49:38 | 11 | 45 |
| 7 |
|
Lokomotiv Moskva | 26 | 11 | 2 | 13 | 45:54 | -9 | 35 |
| 8 |
|
FK Saturn | 26 | 9 | 5 | 12 | 42:63 | -21 | 32 |
| 9 |
|
Kuban Krasnodar | 26 | 7 | 8 | 11 | 28:50 | -22 | 29 |
| 10 |
|
CSKA Moskva | 26 | 8 | 5 | 13 | 51:60 | -9 | 29 |
| 11 |
|
SShOR Zenit | 26 | 7 | 5 | 14 | 33:53 | -20 | 26 |
| 12 |
|
Dinamo Moskva | 26 | 4 | 5 | 17 | 32:59 | -27 | 17 |
| 13 |
|
FShM Moskva | 26 | 4 | 5 | 17 | 30:69 | -39 | 17 |
| 14 |
|
Rubin Kazan | 26 | 2 | 7 | 17 | 22:48 | -26 | 13 |
