 |
 |
|
|
| 19.11.2021 | 17:00 | MFK Ružomberok | - | AS Trenčín | 3:0 (2:0) | |
| 20.11.2021 | 15:00 | FC DAC 1904 | - | FK Senica | 1:0 (0:0) | |
| 15:00 | Zlaté Moravce | - | Spartak Trnava | 0:0 (0:0) | ||
| 15:00 | MŠK Žilina | - | Tatran Liptovský Mikuláš | 2:2 (2:0) | ||
| 15:00 | ŠKF Sereď | - | FK Pohronie | 3:1 (1:1) | ||
| 21.11.2021 | 17:00 | MFK Zemplín Michalovce | - | Slovan Bratislava | 1:2 (1:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Slovan Bratislava | 15 | 12 | 2 | 1 | 38:11 | 27 | 38 |
| 2 |
|
Spartak Trnava | 15 | 10 | 3 | 2 | 24:8 | 16 | 33 |
| 3 |
|
MFK Ružomberok | 15 | 7 | 6 | 2 | 24:12 | 12 | 27 |
| 4 |
|
FC DAC 1904 | 15 | 7 | 3 | 5 | 21:19 | 2 | 24 |
| 5 |
|
MŠK Žilina | 15 | 6 | 4 | 5 | 24:19 | 5 | 22 |
| 6 |
|
AS Trenčín | 15 | 5 | 5 | 5 | 24:22 | 2 | 20 |
| 7 |
|
ŠKF Sereď | 15 | 5 | 4 | 6 | 18:20 | -2 | 19 |
| 8 |
|
MFK Zemplín Michalovce | 15 | 5 | 2 | 8 | 17:22 | -5 | 17 |
| 9 |
|
FK Senica | 15 | 3 | 5 | 7 | 14:23 | -9 | 14 |
| 10 |
|
Tatran Liptovský Mikuláš | 15 | 4 | 2 | 9 | 19:34 | -15 | 14 |
| 11 |
|
Zlaté Moravce | 15 | 2 | 5 | 8 | 15:30 | -15 | 11 |
| 12 |
|
FK Pohronie | 15 | 2 | 3 | 10 | 14:32 | -18 | 9 |
| Playoffs | |
| Relegation |
