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| 03.04.2022 | 13:00 | Adıyamanspor | - | Kahramanmaraşspor | 2:1 (2:1) | |
| 13:00 | Afjet Afyonspor | - | Serik Belediyespor | 1:0 (0:0) | ||
| 13:00 | Ankaraspor | - | Çorum FK | 1:2 (0:1) | ||
| 13:00 | Diyarbekirspor | - | Turgutluspor | 1:0 (0:0) | ||
| 13:00 | Ergene Velimeşe | - | Sakaryaspor | 0:6 (0:2) | ||
| 13:00 | 1461 Trabzon FK | - | Sarıyer SK | 2:3 (1:1) | ||
| 13:00 | Inegölspor | - | Bayburt İl Özel İdare | 1:1 (1:0) | ||
| 13:00 | Niğde Anadolu FK | - | Sivas Belediyespor | 1:1 (0:0) | ||
| 13:00 | Somaspor | - | Bodrumspor | 1:3 (0:2) | ||
| 13:00 | Vanspor FK | - | Etimesgut Belediyespor | 1:2 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 33 | 22 | 8 | 3 | 69:22 | 47 | 74 |
| 2 |
|
1461 Trabzon FK | 33 | 20 | 7 | 6 | 58:26 | 32 | 67 |
| 3 |
|
Bodrumspor | 33 | 19 | 7 | 7 | 54:24 | 30 | 64 |
| 4 |
|
Sivas Belediyespor | 33 | 16 | 9 | 8 | 57:32 | 25 | 57 |
| 5 |
|
Afjet Afyonspor | 33 | 16 | 8 | 9 | 60:35 | 25 | 56 |
| 6 |
|
Vanspor FK | 33 | 15 | 11 | 7 | 45:39 | 6 | 56 |
| 7 |
|
Çorum FK | 33 | 15 | 10 | 8 | 47:30 | 17 | 55 |
| 8 |
|
Bayburt İl Özel İdare | 33 | 15 | 8 | 10 | 40:31 | 9 | 53 |
| 9 |
|
Somaspor | 33 | 15 | 7 | 11 | 48:43 | 5 | 52 |
| 10 |
|
Inegölspor | 33 | 14 | 7 | 12 | 47:44 | 3 | 49 |
| 11 |
|
Ankaraspor | 33 | 12 | 11 | 10 | 48:36 | 12 | 47 |
| 12 |
|
Etimesgut Belediyespor | 33 | 10 | 10 | 13 | 39:49 | -10 | 40 |
| 13 |
|
Diyarbekirspor | 33 | 11 | 5 | 17 | 30:38 | -8 | 38 |
| 14 |
|
Serik Belediyespor | 33 | 10 | 6 | 17 | 39:49 | -10 | 36 |
| 15 |
|
Sarıyer SK | 33 | 9 | 9 | 15 | 38:49 | -11 | 36 |
| 16 |
|
Adıyamanspor | 33 | 11 | 2 | 20 | 40:60 | -20 | 35 |
| 17 |
|
Turgutluspor | 33 | 7 | 10 | 16 | 27:53 | -26 | 31 |
| 18 |
|
Ergene Velimeşe | 33 | 8 | 4 | 21 | 32:67 | -35 | 28 |
| 19 |
|
Niğde Anadolu FK | 33 | 5 | 7 | 21 | 32:73 | -41 | 22 |
| 20 |
|
Kahramanmaraşspor | 33 | 4 | 6 | 23 | 22:72 | -50 | 18 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
